AI Article Synopsis
- - The study aimed to assess the prevalence of significant weight loss after radical cystectomy for bladder cancer and its link to mortality rates, highlighting the importance of nutritional status in surgical recovery.
- - Researchers monitored 71 patients' weight loss over four months post-surgery, finding that 42% experienced substantial weight loss of 10% or more by the end of the first month, which correlated with higher mortality.
- - The findings suggest that significant weight loss might indicate malnutrition and is associated with decreased survival rates, calling for further research on whether improving nutrition can aid recovery and outcomes after surgery.
Article Abstract
Introduction: The purpose of this study was to evaluate the prevalence of postoperative weight loss (WL) following radical cystectomy (RC) and its association with mortality. Nutritional status is recognized as a potential modifiable risk factor for postoperative complications following RC for bladder cancer. The American Society for Parenteral and Enteral Nutrition and the Academy of Nutrition and Dietetics recognize WL as a diagnostic measure for malnutrition.
Methods: Seventy-one patients underwent RC for bladder cancer between July 2008 and July 2013, in whom peri-operative weights were documented regularly. The primary predictor variable was substantial WL defined as ≥ 10% WL by postoperative month 1. Survival was estimated using Kaplan-Meier analysis; logistic regression was used for multivariate analyses.
Results: Mean postoperative WL at 2 weeks was 9.5 lbs (-5.2%), 14.3 lbs (-7.8%) at 1 month, 16.9 lbs (-9.0%) at 2 months, 12.6 lbs (-6.9%) at 3 months, and 8.9 lbs (-4.6%) at 4 months. Forty-two percent of patients met criteria for substantial WL. At 19 months median follow-up, the overall mortality rate was 31% (22 of 71), which rose to 64% (14 of 22) in patients who experienced substantial WL (P < .05). Substantial WL trended towards significance on multivariate analysis (P = .07). There was a significant decrease in 5-year survival in patients with ≥ 10% WL (log rank P < .05).
Conclusions: Patients experience WL following RC, which may be indicative of malnutrition. Substantial WL may predict for poor overall survival. Prospective studies are needed to determine whether nutritional optimization can prevent significant WL and improve outcomes.
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| http://dx.doi.org/10.1016/j.clgc.2016.06.009 | DOI Listing |
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