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Sublingual Minoxidil Increases Fibre Diameter in Male Androgenetic Alopecia. - A proxy for Reversal of Hair Follicle Miniaturization.
Clin Exp Dermatol
January 2025
Tricholab AB, Warsaw, Poland.
Background: The histological hallmark of male androgenetic alopecia (MAGA) is transformation of terminal follicles into miniaturized secondary-vellus follicles. As the volume of the dermal papilla determines the size of the hair bulb and hair fibre diameter, any treatment induced increase in fibre diameter could be used as a proxy for reversal of hair follicle miniaturization. While clinical trials with minoxidil topical solution in MAGA do not demonstrate increased fibre diameter, vellus-to-terminal reconversion is shown in a humanized mouse model treated with MXL.
View Article and Find Full Text PDFDetection of the nuclear translocation of androgen receptor using quantitative and automatic cell imaging analysis.
Tissue Cell
December 2024
Graduate School of Science and Engineering, Iwate University, 4-3-5 Ueda, Morioka, Iwate 020-8551, Japan. Electronic address:
Testosterone signaling mediates diseases such as androgenetic alopecia and prostate cancer and is controlled by the activation of the androgen receptor (AR) and nuclear translocation of the ligand-receptor complex. This study established an immortalized dermal papilla cell line that stably expresses the AR labeled with a monomeric green fluorescence marker. The cells expressed the histone H2B protein as visualized using a red fluorescence marker, enabling the Detection of nuclear translocation under live cell conditions using image analysis.
View Article and Find Full Text PDFAssociation between androgenetic alopecia and risk of cardiovascular events in young males: a systematic review and meta-analysis.
Arch Dermatol Res
December 2024
B.J. Medical College & Civil Hospital, Ahmedabad, Gujarat, India.
Clinical Safety and Efficacy of Dual Wavelength Low-Level Light Therapy in Androgenetic Alopecia: A Double-Blind Randomized Controlled Study.
Dermatol Surg
December 2024
Sinclair DIRECT, Dermatology Investigational Research, Education and Clinical Trials Centre, Melbourne, VIC, Australia.
Background: The light-emitting diode cap being investigated is FDA cleared for the treatment of androgenetic alopecia (AGA).
Objective: Evaluating 3 versions of a red and blue light LED cap: (1) 625- and 660-nm red light, (2) 425-nm blue light, and (3) both 425-nm blue light and 625- and 660-nm red light against sham.
Patients And Methods: Twenty-six-week, multicenter, randomized, controlled, double-blinded study.
The mediation role of sleep on the relationship between drinks behavior and female androgenetic alopecia.
PeerJ
December 2024
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Objectives: To investigate the relationship between drinks behavior and female androgenetic alopecia (AGA) and to clarify the mediating effect of sleep behavior on such relationship.
Methods: A total of 308 female AGA patients and 305 female normal controls were recruited from the hospital, and questionnaires including drinks behavior and sleep behavior were inquired among them. Blood sugar and blood lipids were detected.
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