CRISPR-Cas: Spacer Diversity Determines the Efficiency of Defense.

Curr Biol

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address:

Published: July 2016

Bacterial CRISPR-Cas systems acquire short sequences, called spacers, from viruses and plasmids, leading to adaptive immunity. The diversity of spacers within natural bacterial populations is very high. New data now explain how spacer diversity strengthens resistance of the bacterial population to phage infection.

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http://dx.doi.org/10.1016/j.cub.2016.05.034DOI Listing

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