This paper proposes a generic methodology for the semi-automatic generation of reliable position annotations for evaluating multi-camera people-trackers on large video data sets. Most of the annotation data are automatically computed, by estimating a consensus tracking result from multiple existing trackers and people detectors and classifying it as either reliable or not. A small subset of the data, composed of tracks with insufficient reliability, is verified by a human using a simple binary decision task, a process faster than marking the correct person position. The proposed framework is generic and can handle additional trackers. We present results on a data set of $sim 6$ h captured by 4 cameras, featuring a person in a holiday flat, performing activities such as walking, cooking, eating, cleaning, and watching TV. When aiming for a tracking accuracy of 60 cm, 80% of all video frames are automatically annotated. The annotations for the remaining 20% of the frames were added after human verification of an automatically selected subset of data. This involved $sim 2.4$ h of manual labor. According to a subsequent comprehensive visual inspection to judge the annotation procedure, we found 99% of the automatically annotated frames to be correct. We provide guidelines on how to apply the proposed methodology to new data sets. We also provide an exploratory study for the multi-target case, applied on the existing and new benchmark video sequences.
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Bull Math Biol
January 2025
Bioinformatics and Computational Biology Program, Worcester Polytechnic Institute, Worcester, MA, USA.
Neuroinflammation immediately follows the onset of ischemic stroke in the middle cerebral artery. During this process, microglial cells are activated in and recruited to the penumbra. Microglial cells can be activated into two different phenotypes: M1, which can worsen brain injury; or M2, which can aid in long-term recovery.
View Article and Find Full Text PDFProteomes
January 2025
Research & Development, AbbVie Bioresearch Center, Worcester, MA 01605, USA.
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by repetitive alveolar injuries with excessive deposition of extracellular matrix (ECM) proteins. A crucial need in understanding IPF pathogenesis is identifying cell types associated with histopathological regions, particularly local fibrosis centers known as fibroblast foci. To address this, we integrated published spatial transcriptomics and single-cell RNA sequencing (scRNA-seq) transcriptomics and adopted the Query method and the Overlap method to determine cell type enrichments in histopathological regions.
View Article and Find Full Text PDFJ Chem Inf Model
January 2025
Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, 1218 S 5th Ave, Monrovia, California 91016, United States.
Bayesian network modeling (BN modeling, or BNM) is an interpretable machine learning method for constructing probabilistic graphical models from the data. In recent years, it has been extensively applied to diverse types of biomedical data sets. Concurrently, our ability to perform long-time scale molecular dynamics (MD) simulations on proteins and other materials has increased exponentially.
View Article and Find Full Text PDFEur Heart J Digit Health
January 2025
Klaus Tschira Institute for Integrative Computational Cardiology, University Hospital Heidelberg, Im Neuenheimer Feld 669, 69120 Heidelberg, Germany.
Aims: Data availability remains a critical challenge in modern, data-driven medical research. Due to the sensitive nature of patient health records, they are rightfully subject to stringent privacy protection measures. One way to overcome these restrictions is to preserve patient privacy by using anonymization and synthetization strategies.
View Article and Find Full Text PDFFront Neuroinform
January 2025
Department of Computer Science and Engineering, Institute of Technology, Nirma University, Gujarat, India.
Introduction: The prevalence of age-related brain issues has risen in developed countries because of changes in lifestyle. Alzheimer's disease leads to a rapid and irreversible decline in cognitive abilities by damaging memory cells.
Methods: A ResNet-18-based system is proposed, integrating Depth Convolution with a Squeeze and Excitation (SE) block to minimize tuning parameters.
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