Two antimicrobial P-113 peptide derivatives, P-113Du and P-113Tri, were investigated in this study. Notably, P-113Du and P-113Tri contained significant fractions of α-helix conformation and were less sensitive to high salt and low pH than P-113. Moreover, compared to P-113, these peptides exhibited increased antifungal activity against planktonic cells, biofilm cells, and clinical isolates of Candida albicans and non-albicans Candida spp. These results suggest that P-113Du and P-113Tri are promising candidates for development as novel antifungal agents.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038333 | PMC |
| http://dx.doi.org/10.1128/AAC.00699-16 | DOI Listing |
Publication Analysis
Top Keywords
p-113du p-113tri
16
candida albicans
8
antimicrobial peptides
4
p-113du
4
peptides p-113du
4
p-113tri
4
p-113tri function
4
function candida
4
albicans antimicrobial
4
antimicrobial p-113
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!