Background/aims: is a major risk factor for atrophic gastritis (AG) and gastric cancer. The correlation between , AG and colorectal neoplasm (CRN) has only been examined in a limited number of studies, and findings have been inconclusive. We aimed to investigate the association between infection status, AG and advanced CRN.
Methods: This cross-sectional study investigated the relationship between the presence of serum anti- IgG antibodies, AG, and advanced CRN in 6,351 consecutive asymptomatic subjects who underwent a screening colonoscopy.
Results: A total of 316 participants (5.0%) had advanced CRN. seropositivity was 61.3%. In a univariate analysis, the presence of infection was associated with advanced CRN (odds ratio [OR], 1.49; 95% confidence interval [CI], 1.17 to 1.91; p=0.001). infection was associated with an increased risk of advanced CRN after adjusting for clinically relevant confounders (OR, 1.34; 95% CI, 1.04 to 1.72; p=0.023). -related AG was significantly associated with the risk of advanced CRN (OR, 1.40; 95% CI, 1.03 to 1.91; p=0.030), whereas infection without AG was not.
Conclusions: infection increased the risk of advanced CRN, especially when it was combined with AG. Strict colonoscopy screening and surveillance may be warranted in those with -positive AG.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087929 | PMC |
| http://dx.doi.org/10.5009/gnl15340 | DOI Listing |
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