AI Article Synopsis
- Renal aging leads to increased oxidative stress, but dietary restriction (DR) can help mitigate this effect, particularly through the production of hydrogen sulfide (H2S).
- The study found that a 30% DR for six months or lifelong significantly enhances the production of H2S and improves the expression of key enzymes (CGL and CBS) associated with H2S production, while short-term DR (six weeks) did not show the same benefits.
- Long-term dietary interventions (6 months or lifelong) were more effective in reducing oxidative stress and promoting healthy kidney function in aged rats compared to short-term dietary restriction.
Article Abstract
Renal aging is always accompanied by increased oxidative stress. Hydrogen sulfide (H2S) can be up-regulated by 50% dietary restriction (DR) for 7-day and can block mitochondrial oxidative stress. H2S production exerts a critical role in yeast, worm, and fruit fly models of DR-mediated longevity. In this study, we found that renal aging could be attenuated by 30% DR for 6-month (DR-6M) and life-long (DR-LL), but not for 6-week (DR-6W). The expressions of cystathionine-γ-lyase (CGL) and cystathionine-β- synthase (CBS) were improved by DR-6M and DR-LL. Endogenous H2S production shared the same trend with CBS and CGL, while glutathione (GSH) didn't. When comparing efficiencies of DR for different durations, more evident production of H2S was found in DR-6M and DR-LL than in DR-6W. Finally the level of oxidative stress was improved by DR-6M and DR-LL rather than by DR-6W. It concluded that aged rats had the ability to produce enough H2S on 30% DR interventions protecting against renal aging, and the effect of DR for long-term were more significant than that of DR for short-term.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960595 | PMC |
| http://dx.doi.org/10.1038/srep30292 | DOI Listing |
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