AI Article Synopsis
- This study explores the use of CdSe/ZnS core/shell quantum dots (QDs) to enhance oxidation reactions of 5-aminolevulinic acid (ALA) and glutamate (GLU), leading to the generation of reactive oxygen species (ROS).
- The research demonstrates that MPA-capped QDs significantly increase the efficiency of these reactions under LED light, producing hydroxyl radicals from ALA and superoxide anions from GLU.
- Additionally, the combination of QDs with coumarin-derived dendrimer-coated silica particles boosts singlet oxygen production by 80%, while confocal microscopy confirms ROS production in HeLa cells under the same conditions.
Article Abstract
In this present work, CdSe/ZnS core/shell quantum dots (QDs) were exploited in the oxidation reactions of 5-aminolevulinic acid (ALA) and glutamate (GLU) for the production of reactive oxygen species (ROS). Fast and highly efficient oxidation reactions of ALA to produce the hydroxyl radicals (HO*) and of GLU to produce the superoxide anion (O2*-) were observed in the cooperation of mercaptopropionic acid (MPA) capped-CdSe/ZnS QDs (MPA-QDs) under LED irradiation. Whereas, binding between MPA-QDs and coumarin-derived dendrimer (CdD)-captured silica particles (SiCdDs) through sol-gel GA enhanced singlet oxygen production under LED irradiation by about 80% as compared to that achieved using QDs only. Confocal fluorescent microscopic images of the size and morphology of HeLa cells confirmed the ROS production from ALA, GLU in cooperation with CdSe/ZnS QDs or QDs-coated SiCdDs under LED irradiation.
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| http://dx.doi.org/10.1166/jnn.2016.10787 | DOI Listing |
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