The analysis was applied to microflora of feces and oropharinx and concentration of volatile fatty acids in saliva from patients of consultative diagnostic center of G.N. Gabrichevskii Moscow research institute of epidemiology and microbiology. The computer classification program is developed on the basis of determining degree of microbiological disorders on the basis of received data and using artificial neural networks and discriminant analysis. The analysis established decreasing of probability of false classification in case of increasing of degree of microbiological disorders of microflora of intestine and absence of such a correlation for microbiological and metabolic disorders of microflora of intestine.
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Int J Med Sci
January 2025
Medical Oncology Department of Gastrointestinal Cancer, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, No.44 Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, China.
Gastric cancer (GC) remains a significant global health challenge. This study aimed to comprehensively analyze GC epidemiology and risk factors to inform prevention and intervention strategies. We analyzed the Global Burden of Disease Study 2021 data, conducted 16 different machine learning (ML) models of NHANES data, performed Mendelian randomization (MR) studies on disease phenotypes, dietary preferences, microbiome, blood-based markers, and integrated differential gene expression and expression quantitative trait loci (eQTL) data from multiple cohorts to identify factors associated with GC risk.
View Article and Find Full Text PDFNAR Genom Bioinform
March 2025
Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Metagenotyping of metagenomic data has recently attracted increasing attention as it resolves intraspecies diversity by identifying single nucleotide variants. Furthermore, gene copy number analysis within species provides a deeper understanding of metabolic functions in microbial communities. However, a platform for examining metagenotyping results based on relevant grouping data is lacking.
View Article and Find Full Text PDFFASEB Bioadv
January 2025
Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics The First Dongguan Affiliated Hospital, Guangdong Medical University Dongguan Guangdong China.
Copper is a vital trace element crucial for mediating interactions between and macrophages. Within these immune cells, copper modulates oxidative stress responses and signaling pathways, enhancing macrophage immune functions and facilitating clearance. Conversely, copper may promote escape from macrophages through various mechanisms: inhibiting macrophage activity, diminishing phagocytic and bactericidal capacities, and supporting survival and proliferation.
View Article and Find Full Text PDFCan Vet J
January 2025
Department of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, 2015 SW 16th Avenue, Gainesville, Florida 32608, USA (Whitman); Gulf Coast Veterinary Specialists, 8042 Katy Freeway, Houston, Texas 77024, USA (Wilson); Department of Small Animal Clinical Sciences, Texas A&M School of Veterinary Medicine and Biomedical Sciences, 4474 TAMU, College Station, Texas 77843, USA (Heseltine).
Canine systemic protothecosis is an uncommon disease caused by spp., which are saprophytic algae occurring ubiquitously in nature. Infection occurs most commonly in immunocompromised animals.
View Article and Find Full Text PDFCan Vet J
January 2025
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, 2015 SW 16th Avenue, PO Box 100126, Gainesville, Florida 32610-012, USA (Perez-Rodriguez, Kidd, Wolf); IFAS Statistical Consulting, University of Florida, 402 McCarty Hall C, PO Box 110339, Gainesville, Florida 32611-0339, USA (Colee).
Objective: The objective was to assess whether cholesterol concentration at admission was associated with outcome and disease severity in dogs with sepsis, and to determine whether there was a significant difference in cholesterol between dogs with gram-positive gram-negative sepsis.
Animals And Procedure: Electronic medical records of dogs diagnosed with sepsis at a tertiary teaching hospital from 2012 to 2022 were evaluated. A total of 299 dogs were included.
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