High throughput screening of a 4096 compound library of boronic acid and acridine containing branched peptides revealed compounds that have dissociation constants in the low nanomolar regime for HIV-1 RRE IIB RNA. We demonstrate that branched peptide boronic acids , , and inhibit the production of p24, an HIV-1 capsid protein, in a dose-dependent manner.
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| http://dx.doi.org/10.1039/C6MD00171H | DOI Listing |
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