The present study was carried out to examine whether γ-aminobutyric acid (GABA) receptor mechanisms are involved in the release of serotonin (5-hydroxytryptamine, 5-HT) in the subfornical organ (SFO) using intracerebral microdialysis techniques. Perfusion with the GABA receptor antagonists as well as agonists was performed in the region of the SFO through a microdialysis probe and extracellular concentrations of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) were measured in freely moving rats. Perfusion with the GABAA receptor antagonist bicuculline (10 and 50μM), but not the GABAB receptor antagonist phaclofen (10 and 50μM), increased dialysate 5-HT and 5-HIAA concentrations in the SFO area, suggesting that the GABAergic system may tonically inhibit the 5-HT release in the SFO area through GABAA receptors. Higher perfusion with the GABAA receptor agonist muscimol (50μM) or the GABAB receptor agonist baclofen (250μM) decreased extracellular levels of 5-HT and 5-HIAA in the SFO area. Nonhypotensive hypovolemia induced by subcutaneous injection of polyethylene glycol (PEG, 30%, 5ml) significantly enhanced the 5-HT and 5-HIAA concentrations in the SFO area. The enhanced 5-HT and 5-HIAA levels elicited the PEG treatment were reduced by perfusion with muscimol (10μM), but not by baclofen (50μM). These results show the involvement of both GABAA and GABAB receptors in the modulation of the 5-HT release in the SFO area, and imply that the GABAA receptor mechanism may be importance for the serotonergic regulatory system of body fluid balance.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neulet.2016.07.040 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genomic analysis of IMP-8-producing Enterobacter hormaechei with a novel plasmid pK432-IMP.
J Glob Antimicrob Resist
December 2024
Department of Clinical Laboratory Medicine, Taizhou Municipal Hospital, Taizhou, China. Electronic address:
Article Synopsis
- * The strain K432 was found to carry six drug-resistant genes and features a complex genome structure, including a main chromosome and three plasmids, with pK432-IMP representing a novel plasmid type.
- * Findings highlight the need for ongoing surveillance of multidrug-resistant E. hormaechei strains in China to better understand and manage the threat posed by these pathogens.
Silicon dioxide incorporated cellulose acetate-mixed matrix membranes for Safranin-O removal from aqueous solutions.
Environ Sci Pollut Res Int
October 2024
Department of Chemical Engineering, National Institute of Technology Warangal, Hanumakonda, Telangana State, India, 506 004.
Nanoparticle incorporated-mixed matrix membranes are renowned for their multifaceted advantages, including improved hydrophilicity, elevated solute rejection, enhanced mechanical robustness, and augmented chemical and thermal stability. The inherent hydrophilicity of silicon dioxide (SiO) nanoparticles, due to silanol groups (Si-OH), along with their high porosity and surface area, renders them an ideal reinforcing filler within polymer matrices, significantly strengthening structural integrity of membranes. In this work, SiO nanoparticles were incorporated in a cellulose acetate (CA) matrix to prepare CA/SiO adsorptive membranes using phase inversion method.
View Article and Find Full Text PDFAssociation Between Accelerometer-Assessed Physical Activity and Cognitive Function in Older Adults: A Cross-Sectional Study.
Am J Geriatr Psychiatry
October 2024
Aging Research Center, Department of Neurobiology, Care Sciences and Society (NVS), (JA, ACL, GB, EJL, AKW), Karolinska Institutet and Stockholm University, Stockholm, Sweden; Stockholm Gerontology Research Center (ACL, EJL, AKW), Stockholm, Sweden; Division of Physiotherapy (AKW), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Women´s Health and Allied Health Professionals Theme (AKW), Medical Unit Medical Psychology, Karolinska University Hospital, Stockholm, Sweden.
Objective: Research suggests that physical activity (PA) improves cognitive function across various domains. However, the specific role of different PA measures, including step count, remains to be explored. Our aim was to assess the correlation between objectively measured PA and cognitive function.
View Article and Find Full Text PDFA Density Functional Benchmark for Dehydrogenation and Dehalogenation Reactions on Coinage Metal Surfaces.
Chemphyschem
October 2024
Materials Design Division, Department of Physics, Chemistry and Biology, IFM, Linköping University, 58183, Linköping, Sweden.
Article Synopsis
- Researchers explored the on-surface synthesis of organic nanostructures using density functional theory (DFT) and examined how different DFT approaches impact the results.
- Five methods, including variations that account for van der Waals (vdW) interactions, were tested on three reactions involving benzene derivatives on metal surfaces.
- The study found that rev-vdW-DF2 was the most effective for benzene adsorption, while BEEF-vdW performed poorly; all methods, except BEEF-vdW, generally provided reasonable activation energies for dehydrogenation and debromination reactions.
Palladium-Doped CsAgBiBr with 1300 nm Near-Infrared Photoresponse.
Small
December 2024
Department of Physics, Chemistry and Biology (IFM), Linköping University, Linköping, SE-581 83, Sweden.
Lead-free halide double perovskite (HDP) CsAgBiBr has set a benchmark for research in HDP photoelectric applications due to its attractive optoelectronic properties. However, its narrow absorption range is a key limitation of this material. Herein, a novel dopant, palladium (Pd), is doped into CsAgBiBr and significantly extends the absorption to ≈1400 nm.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!