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Trends in Preventive Aspirin Use by Atherosclerotic Cardiovascular Risk.
JAMA
January 2025
Division of General Internal Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Does Nonsteroidal Anti-inflammatory Drug Use Modify All-Cause and Cause-Specific Mortality Associated with PM and Its Components? A Nationally Representative Cohort Study (2007-2017).
Environ Health (Wash)
January 2025
Institute of Medical Technology, Peking University Health Science Center, Beijing 100191, China.
Several studies reported that nonsteroidal anti-inflammatory drug (NSAID) use could alleviate subclinical effects of short-term exposure to fine particulate matter (PM). However, whether chronic NSAID use could mitigate the long-term effects of PM and its components on population mortality has been unknown. Based on a national representative survey of 47,086 adults (2007-2010) with follow-up information on the primary cause of death (until 2017), we investigated the long-term associations of PM and its major components, including black carbon (BC), ammonium (NH ), nitrate (NO ), organic matter (OM), and sulfate (SO ), with all-cause and cause-specific mortality using the Cox proportional hazards model.
View Article and Find Full Text PDFPreterm preeclampsia screening and prevention: a comprehensive approach to implementation in a real-world setting.
BMC Pregnancy Childbirth
January 2025
Genetic Program, North York General Hospital, Toronto, ON, Canada.
Background: Preeclampsia significantly impacts maternal and perinatal health. Early screening using advanced models and primary prevention with low-dose acetylsalicylic acid for high-risk populations is crucial to reduce the disease's incidence. This study assesses the feasibility of implementing preterm preeclampsia screening and prevention by leveraging information from our current aneuploidy screening program in a real-world setting with geographic separation clinical site and laboratory analysis site.
View Article and Find Full Text PDFExploring knowledge of first aid in epistaxis-25 years on.
PLoS One
January 2025
Department of Otolaryngology, Cambridge University Hospitals Trust, Cambridge, United Kingdom.
Background: Epistaxis is the most common acute disorder managed by ENT services. A 1998 survey (Strachan and England) demonstrated widespread ignorance of correct first aid amongst the public with only 11% of respondents applying correct first aid techniques. Here we repeated and expanded the 1998 study to investigate whether understanding of correct first aid in epistaxis amongst the public and emergency department staff has improved in the last 25 years.
View Article and Find Full Text PDFBlood absolute lymphocyte count and trajectory are important in understanding severe COVID-19.
BMC Infect Dis
January 2025
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Background: Low blood absolute lymphocyte count (ALC) may predict severe COVID-19 outcomes. Knowledge gaps remain regarding the relationship of ALC trajectory with clinical outcomes and factors associated with lymphopenia.
Methods: Our post hoc analysis of the Therapeutics for Inpatients with COVID-19 platform trial utilized proportional hazards models to assess relationships between Day (D) 0 lymphopenia (ALC < 0.
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