AI Article Synopsis
- Liquid chromatography (LC) combined with mass spectrometry (MS) is a key technique in clinical, forensic toxicology, and doping control for effectively analyzing drugs and their metabolites.
- New methods for multi-target screening have been developed, particularly aimed at addressing the rising prevalence of new psychoactive substances in recreational markets.
- Recent advancements in high-resolution mass spectrometry and data-independent detection are enhancing systematic toxicological screening methods, with an emphasis on literature released since 2010.
Article Abstract
Liquid chromatography (LC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) is a well-established and widely used technique in clinical and forensic toxicology as well as doping control especially for quantitative analysis. In recent years, many applications for so-called multi-target screening and/or quantification of drugs, poisons, and or their metabolites in biological matrices have been developed. Such methods have proven particularly useful for analysis of so-called new psychoactive substances that have appeared on recreational drug markets throughout the world. Moreover, the evolvement of high resolution MS techniques and the development of data-independent detection modes have opened new possibilities for applications of LC-(MS/MS) in systematic toxicological screening analysis in the so called general unknown setting. The present paper will provide an overview and discuss these recent developments focusing on the literature published after 2010.
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| http://dx.doi.org/10.1016/j.clinbiochem.2016.07.010 | DOI Listing |
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