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Efficacy and potential mechanism of atherosclerosis prevention by the active components of leech based on network pharmacology combined with animal experiments.
Heliyon
March 2024
Clinical Pharmacy Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Article Synopsis
- Leeches, known for their bloodsucking and flesh-eating characteristics, have a long history in traditional Chinese medicine, with active components like hirudin showing potential in treating blood circulation issues and thrombosis.
- The study utilized network pharmacology to identify and analyze potential targets of leech constituents related to atherosclerosis (AS), leading to the construction of a target-pathway network.
- Results indicated that leech extracts affected 89 common targets related to AS, with 12 core targets identified, and animal models showed that leech treatment resulted in reduced plaque size in atherosclerotic mice.
Worms and Flesh-Eating Bacteria? The Worst Day of Your Life.
Ann Emerg Med
August 2016
Department of Emergency Medicine, University of Southern California, Los Angeles, CA.
Group A Streptococcus (GAS) causes human infections that range in severity from pharyngitis ("strep-throat") to necrotizing fasciitis ("flesh-eating disease"). To facilitate investigation of the molecular basis of host-pathogen interactions, infection models capable of rapidly screening for differences in GAS strain virulence are needed. To this end, we developed a Galleria mellonella larvae (wax worm) model of invasive GAS infection and used it to compare the virulence of serotype M3 GAS strains.
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