AI Article Synopsis
- The study aimed to assess the role of polymorphisms in APLN and APLNR genes as potential markers for hypertension in Mexican-Mestizo patients through a case-control approach involving 400 normotensive and 383 hypertensive subjects.
- The findings revealed that specific polymorphisms of the APLNR gene (rs7119375 and rs10501367) significantly decreased the risk of essential hypertension when adjusted for various health factors, while APLN gene polymorphisms showed no significant association.
- Additionally, haplotype analysis indicated that the H1 haplotype increased the risk of essential hypertension, whereas the H2 haplotype decreased it, suggesting the need for further research in this area.
Article Abstract
The aim of this study was to evaluate if polymorphisms of APLN and APLNR genes may play a role as susceptibility markers for hypertension in a group of Mexican-Mestizo patients. A case-control study was carried out including normotensive and hypertensive individuals. For these, two polymorphisms of APLN (rs3761581 and rs56204867) and two of APLNR () genes were genotyped by 5' exonuclease TaqMan assay in 400 normotensive individuals and 383 patients. The results showed that, under an additive model adjusted by BMI, HDL, triglycerides, glucose and family history of essential hypertension, the rs7119375 and rs10501367 polymorphisms of APLNR gene were associated significantly with a decreased risk of essential hypertension (P=0.039 and P=0.029, respectively). Besides, the haplotypes analysis of these polymorphisms showed that H1 haplotype was associated with an increased risk of essential hypertension (P=0.026), while the H2 haplotype was associated with a decreased risk (P=0.032). Contrary, the rs3761581 and rs56204867 polymorphisms of APLN gene were not associated with essential hypertension (P=0.1707 and P=0.0769, respectively). The data suggest that APLNR rs7119375 and rs10501367 are associated with a decreased risk of essential hypertension in our Mexican-Mestizo studied group, but further studies are warranted.
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| http://dx.doi.org/10.1016/j.yexmp.2016.07.007 | DOI Listing |
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