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MRgFUS disconnection surgery for hypothalamic hamartoma-related epilepsy: case report and literature review.
Neurol Sci
December 2024
Neurology Unit, Department of Neurosciences, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Background: Drug-resistant epilepsy (DRE) secondary to hypothalamic hamartoma (HH) often requires surgical resection or stereotactic radiosurgery, which frequently fail to provide satisfactory outcomes and are associated with severe side effects. Magnetic resonance-guided focused ultrasound (MRgFUS) may represent a minimally invasive surgical approach to HH by offering precise thermal ablation of sub-millimetric brain targets while sparing surrounding structures.
Methods: We present the case of a 19-year-old man with HH-associated DRE, who was successfully treated with MRgFUS.
Feasibility of quantitative relaxometry for prostate target localization and response assessment in magnetic resonance-guided online adaptive stereotactic body radiotherapy.
Phys Imaging Radiat Oncol
October 2024
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Purpose: Multiparametric magnetic resonance imaging (MRI) is known to provide predictors for malignancy and treatment outcome. The inclusion of these datasets in workflows for online adaptive planning remains under investigation. We demonstrate the feasibility of longitudinal relaxometry in online MR-guided adaptive stereotactic body radiotherapy (SBRT) to the prostate and dominant intra-prostatic lesion (DIL).
View Article and Find Full Text PDFHerpes Simplex Oncolytic Viral Therapy for Malignant Glioma and Mechanisms of Delivery.
World Neurosurg
December 2024
Department of Neurological Surgery, the University of Alabama at Birmingham, Birmingham, AL, USA.
The authors present a comprehensive review on the history and development of oncolytic herpes simplex viral therapies for malignant glioma with a focus on mechanisms of delivery in prior and ongoing clinical trials. This review highlights the advancements made with regard to delivering these therapies to a highly complex immunologic environment in the setting of the blood brain and blood tumor barrier in a safe and effective manner.
View Article and Find Full Text PDFPersonalized deep learning auto-segmentation models for adaptive fractionated magnetic resonance-guided radiation therapy of the abdomen.
Med Phys
December 2024
Department of Radiation Oncology, LMU University Hospital, LMU Munich, Munich, Germany.
Background: Manual contour corrections during fractionated magnetic resonance (MR)-guided radiotherapy (MRgRT) are time-consuming. Conventional population models for deep learning auto-segmentation might be suboptimal for MRgRT at MR-Linacs since they do not incorporate manual segmentation from treatment planning and previous fractions.
Purpose: In this work, we investigate patient-specific (PS) auto-segmentation methods leveraging expert-segmented planning and prior fraction MR images (MRIs) to improve auto-segmentation on consecutive treatment days.
Diffusion-weighted imaging as a non-gadolinium alternative for immediate assessing nonperfused area of adenomyosis after magnetic resonance-guided focused ultrasound (MRgFUS) ablation: a potential technique but with slightly overestimate.
Quant Imaging Med Surg
December 2024
Center of MRgFUS, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan, China.
Background: It is a technical challenge to monitor ablation outcome during magnetic resonance-guided focused ultrasound (MRgFUS) treatment using non-gadolinium technique. The study aimed to investigate the value of diffusion-weighted imaging (DWI) for immediately assessing nonperfused area of adenomyosis after MRgFUS treatment.
Methods: We retrospectively included patients with adenomyosis who underwent MRgFUS ablation and underwent both DWI (b=800 sec/mm) and contrast-enhanced (CE) magnetic resonance (MR) imaging within 15 minutes after treatment.
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