In this study, we examined the role of the miRNA miR-770-5p in cisplatin chemotherapy resistance in ovarian cancer (OVC) patients. miR-770-5p expression was reduced in platinum-resistant patients. Using a 6.128-fold in expression as the cutoff value, miR-770-5p expression served as a prognostic biomarker and predicted the response to cisplatin treatment and survival among OVC patients. Overexpression of miR-770-5p in vitro reduced survival in chemoresistant cell lines after cisplatin treatment. ERCC2, a target gene of miR-770-5p that participates in the NER system, was negatively regulated by miR-770-5p. siRNA-mediated silencing of ERCC2 reversed the inhibition of apoptosis resulting from miR-770-5p downreglation in A2780S cells. A comet assay confirmed that this restoration of cisplatin chemosensitivity was due to the inhibition of DNA repair. These findings suggest that endogenous miR-770-5p may function as an anti-oncogene and promote chemosensitivity in OVC, at least in part by downregulating ERCC2. miR-770-5p may therefore be a useful biomarker for predicting chemosensitivity to cisplatin in OVC patients and improve the selection of effective, more personalized, treatment strategies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288183 | PMC |
| http://dx.doi.org/10.18632/oncotarget.10736 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Online video versus face-to-face patient-surgeon consultation: a systematic review.
Surg Endosc
December 2024
Department of Surgery, Amsterdam UMC, Location University of Amsterdam, Amsterdam, The Netherlands.
Background: Online video consultation (OVC) is increasingly used in patient-surgeon pre-surgical and follow-up consultation but a comprehensive review assessing its benefits and downsides as compared to face-to-face (F2F) consultation is currently lacking. This systematic review evaluated the effectiveness of OVC as compared to F2F consultation.
Methods: A literature search (Ovid/Medline, Embase, and Clarivate Analytics/Web of Science Core Collection) was conducted including studies comparing efficacy, patient and surgeon satisfaction, and information recall between OVC and F2F patient-surgeon consultation (inception-December 4, 2023).
Sensitive and Cost-Effective Tools in the Detection of Ovarian Cancer Biomarkers.
Anal Sci Adv
October 2024
Cardiovascular Research Center, Tehran Tehran University of Medical Sciences Tehran Iran.
Article Synopsis
- Women with late-stage ovarian cancer face high mortality rates, making early detection crucial for improving outcomes.
- Large-scale screening using blood biomarkers is essential, with current clinical focus primarily on cancer antigen 125 (CA125), despite its limitations.
- The text reviews recent advances in biosensor technology for detecting ovarian cancer biomarkers like CA125, HE4, and apolipoprotein A1, while also addressing the challenges and scarcity of biosensors for this disease.
Potential of photodynamic therapy as a minimally invasive treatment for oral verrucous carcinoma.
Photodiagnosis Photodyn Ther
October 2024
Electrodiagnosis Department, Jilin FAW General Hospital, Jilin University, Changchun, PR China.
Article Synopsis
- - Oral verrucous carcinoma (OVC) and proliferative verrucous leukoplakia (PVL) may originate similarly and pose an increased risk of cancer when they occur together, especially in older patients.
- - Photodynamic therapy (PDT) is a non-invasive treatment option that uses light to activate substances that target and destroy malignant cells, offering a safer treatment method for those with these conditions.
- - In a case study, an elderly patient with both PVL and OVC underwent PDT, resulting in complete remission with no recurrence after 10 months, while maintaining good oral appearance and function.
Telomere length as a predictor of therapy response and survival in patients diagnosed with ovarian carcinoma.
Heliyon
July 2024
Toxicogenomics Unit, National Institute of Public Health, Srobarova 48, 100 42, Prague, Czech Republic.
Impaired telomere length (TL) maintenance in ovarian tissue may play a pivotal role in the onset of epithelial ovarian cancer (OvC). TL in either target or surrogate tissue (blood) is currently being investigated for use as a predictor in anti-OvC therapy or as a biomarker of the disease progression, respectively. There is currently an urgent need for an appropriate approach to chemotherapy response prediction.
View Article and Find Full Text PDFMast Cell-related Prognosis Signature Characterizes Immune Landscape and Predicts Prognosis of Ovarian Cancer.
Anticancer Res
July 2024
Department of Intensive Care Unit, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China;
Article Synopsis
- Ovarian cancer (OVC) is aggressive with a variable prognosis, and the role of mast cells in its prognosis is not well understood.
- Researchers used a dataset from The Cancer Genome Atlas to identify 29 mast cell-associated prognostic genes, developing a model to classify OVC based on these genes.
- The study found that low mast cell gene scores correlate with better patient outcomes and responses to immunotherapy and chemotherapy, potentially enhancing personalized treatment strategies for OVC patients.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!