Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/0284186X.2016.1206212 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of Hedgehog modulators on signaling pathways in primary murine and human hepatocytes in vitro: insights into liver metabolism.
Arch Toxicol
December 2024
Faculty of Medicine, Rudolf Schönheimer Institute of Biochemistry, Leipzig University, Leipzig, Germany.
The Hedgehog (Hh) signaling pathway is essential for maintaining homeostasis during embryogenesis and in adult tissues. In the liver, dysregulation of this pathway often leads to liver cancer development. Recent studies also suggest that disturbances in the Hh pathway can affect liver metabolism in healthy livers through interactions with other signaling pathways, such as the Wnt/β-catenin pathway.
View Article and Find Full Text PDFInhibition of Hedgehog Signaling Ameliorates Severity of Chronic Pancreatitis in Experimental Mouse Models.
Am J Physiol Gastrointest Liver Physiol
November 2024
Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Article Synopsis
- Chronic pancreatitis (CP) is an inflammatory disease of the pancreas without a specific cure, and this study investigates the role of the hedgehog signaling pathway in its progression.
- The researchers induced CP in mice and used the FDA-approved drug Vismodegib to inhibit the hedgehog pathway, assessing its effects on the disease's severity.
- Results showed that inhibiting hedgehog signaling improved disease parameters, halted progression, and reversed fibrosis, suggesting Vismodegib could be a promising new treatment for CP in clinical settings.
Transcriptomic Analysis of Early-Stage Basal Cell Carcinomas in Murine Skin Following Topical Treatments With Ablative Fractional Laser and Vismodegib.
Exp Dermatol
October 2024
Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Article Synopsis
- A study using RNA sequencing showed that BCC induction in murine skin resulted in significant gene upregulation, with treatments like AFL and the hedgehog inhibitor vismodegib reversing these changes, though vismodegib was more effective.
- Both treatments increased immune cell infiltration in the skin, with AFL notably recruiting a larger number of immune cells, suggesting different mechanisms at play that could inform future combined treatment strategies.
Cancer Stem Cells in Oral Squamous Cell Carcinoma: A Narrative Review on Experimental Characteristics and Methodological Challenges.
Biomedicines
September 2024
Department of Oral Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Cancer stem cells (CSCs) represent a subpopulation of cancer cells that are believed to initiate and drive cancer progression. In animal models, xenotransplanted CSCs have demonstrated the ability to produce tumors. Since their initial isolation in blood cancers, CSCs have been identified in various solid human cancers, including oral squamous cell carcinoma (OSCC).
View Article and Find Full Text PDFInherited Basaloid Neoplasms Associated With SUFU Pathogenic Variants.
JAMA Dermatol
November 2024
Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
Article Synopsis
- This study investigates the range of skin conditions in patients with germline SUFU pathogenic variants (PVs), focusing on their clinical and histopathologic features.* -
- Conducted across U.S. dermatology and genetics clinics over eight years, the study analyzed skin biopsy samples from five female patients aged 31-68, identifying several types of skin tumors.* -
- Findings reveal that alongside typical basal cell carcinomas, these patients exhibit various indolent skin lesions, indicating a broader range of cutaneous manifestations associated with SUFU PVs.*
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!