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Clinical investigation of the safety and efficacy of a cervical intraepithelial neoplasia treatment using a hyperthermia device that uses heat induced by alternating magnetic fields. | LitMetric

AI Article Synopsis

  • Several techniques exist for treating high-grade cervical intraepithelial neoplasia (HG-CIN) in fertile women, each with potential complications such as cervical stenosis, canal shortening, and risks during childbirth.
  • The study investigated the safety and efficacy of a new treatment method, the AMTC400 device, on four premenopausal patients with CIN3 and high-risk HPV, which was performed without anesthesia and resulted in minor complications like pain and bleeding.
  • After treatment, 50% of the patients tested negative for high-risk HPV, and while initial analysis showed no intraepithelial lesions, histology revealed CIN1 and koilocytosis, indicating moderate treatment effectiveness.

Article Abstract

Multiple techniques have been used for the conservative treatment of high-grade cervical intraepithelial neoplasia (HG-CIN) in women of fertile age. Conization has been associated with stenosis of the cervix and a decrease in cervical mucus secretion, in addition to the increase in the risk of cervical canal shortening and problems during the perinatal period, including premature birth and premature rupture of membranes. Although the laser transpiration technique does not cause shortening of the cervical canal, it is associated with the recurrent risk of deep residual disease. The present study aimed to investigate the therapeutic safety and efficacy of the therapy performed using the transaction magnetic field induction heating device, AMTC400, in fertile patients with HG-CIN (excluding carcinoma ). Four premenopausal patients with CIN3 and high-risk human papilloma virus (HPV)-positive were treated using an AMTC400. Chronological colposcopic findings, high-risk HPV, final histological findings with conization and follow-up data were evaluated. All the treatments were successfully performed on the in-patients without anesthesia. Intra- and postoperative complications included minor pain and bleeding in all cases. Two of the cases (50%) were high-risk HPV-negative following the treatments. All cases exhibited a change in the observed color (to white), and subsequent epithelization following treatment. Although cytological analysis at 5 weeks following the treatment confirmed the cases were negative for intraepithelial lesions and malignancies, a definitive histology with conization 6 weeks following the treatment confirmed CIN1 and koilocytosis in all cases. The assessment of treatment effectiveness was determined as a moderate improvement in all cases. In conclusion, thermotherapy applied using AMTC400 represented a safe and effective treatment for HG-CIN in women of fertile age. However, additional improvements associated with the site of puncture needles are required. Further studies are required to confirm the long-term efficacy and reproductive outcomes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950731PMC
http://dx.doi.org/10.3892/mco.2016.929DOI Listing

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