AI Article Synopsis
- BK channels play crucial roles in kidney functions, specifically in podocytes, where they respond to increased calcium levels triggered by TRPC6 channel activation.
- Insulin enhances the permeability of the filtration barrier in the kidney by mobilizing BK channels.
- The review focuses on new findings regarding BK channels in the glomerulus, detailing their physiological and pathological functions, especially in mesangial cells to counteract contraction effects.
Article Abstract
Large-conductance calcium-activated potassium (BK) channels are currently considered as vital players in a variety of renal physiological processes. In podocytes, BK channels become active in response to stimuli that increase local cytosolic Ca(2+), possibly secondary to activation of slit diaphragm TRPC6 channels by chemical or mechanical stimuli. Insulin increases filtration barrier permeability through mobilization of BK channels. In mesangial cells, BK channels co-expressed with β1 subunits act as a major component of the counteractive response to contraction in order to regulate glomerular filtration. This review aims to highlight recent discoveries on the localization, physiological and pathological roles of BK channels in glomerulus.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915313 | PMC |
| http://dx.doi.org/10.3389/fphys.2016.00248 | DOI Listing |
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