Approaches to characterizing and developing understanding around the mechanisms that control the release of drugs from hydrophilic matrix tablets are reviewed. While historical context is provided and direct physical characterization methods are described, recent advances including the role of percolation thresholds, the application on magnetic resonance and other spectroscopic imaging techniques are considered. The influence of polymer and dosage form characteristics are reviewed. The utility of mathematical modeling is described. Finally, how all the information derived from applying the developed mechanistic understanding from all of these tools can be brought together to develop a robust and reliable hydrophilic matrix extended-release tablet formulation is proposed.

Download full-text PDF

Source
http://dx.doi.org/10.4155/tde-2016-0026DOI Listing

Publication Analysis

Top Keywords

hydrophilic matrix
12
mechanistic understanding
8
matrix tablets
8
advances mechanistic
4
understanding release
4
release rate
4
rate control
4
control mechanisms
4
mechanisms extended-release
4
extended-release hydrophilic
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!