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Integrating post-validation surveillance of lymphatic filariasis with the WHO STEPwise approach to non-communicable disease risk factor surveillance in Niue, a study protocol.
PLoS One
January 2025
Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia.
Background: Lymphatic filariasis (LF), a mosquito-borne parasitic disease caused by three species of filarial worms, was first detected in Niue, a small Pacific Island nation of approximately 1,600 people, in 1954. After extensive efforts involving multiple rounds of Mass Drug Administration, Niue was validated by the World Health Organization (WHO) as having e4liminated LF as a public health problem in 2016. However, no surveillance has been conducted since validation to confirm infection rates have remained below WHO's elimination threshold.
View Article and Find Full Text PDFThe effects of variable spatial aggregation on lymphatic filariasis transmission.
Parasit Vectors
January 2025
National Centre for Epidemiology and Population Health, Australian National University, 62 Mills Road, Canberra, 2601, ACT, Australia.
Background: Elimination of lymphatic filariasis (LF) is a World Health Organization goal, with several countries at or near prevalence thresholds. Where LF cases remain after mass drug administration, they tend to be spatially clustered, with an overdispersed individual worm burden. Both individual and spatial heterogeneities can cause aggregation of infection; however, few studies have investigated the drivers of heterogeneity and implications for disease elimination.
View Article and Find Full Text PDFGenome-Wide Analysis Reveals Key Genes and MicroRNAs Related to Pathogenic Mechanism in .
Pathogens
December 2024
School of Artificial Intelligence, Hangzhou Dianzi University, Hangzhou 310018, China.
is a parasite transmitted by mosquitoes and can cause a neglected tropical disease called Lymphatic filariasis. However, the genome of was not well studied, making novel drug development difficult. This study aims to identify microRNA, annotate protein function, and explore the pathogenic mechanism of by genome-wide analysis.
View Article and Find Full Text PDFMicroRNAs secreted by the parasitic nematode Brugia malayi disrupt lymphatic endothelial cell integrity.
PLoS Negl Trop Dis
December 2024
Systems Genomics Section, Laboratory of Parasitic Diseases, Division of Intramural Research, NIAID, NIH, Bethesda, Maryland, United States of America.
Lymphatic filariasis (LF) is a neglected tropical disease affecting over 51 million people in 72 endemic countries. Causative agents of LF are mosquito-borne parasitic nematodes Wuchereria bancrofti, Brugia malayi, and Brugia timori. The adult parasites impact the integrity of lymphatic vessels and damage valves, leading to a remodeling of the lymphatic system and lymphatic dilation.
View Article and Find Full Text PDFDesigning and comparative analysis of anti-oxidant and heat shock proteins based multi-epitopic filarial vaccines.
BMC Infect Dis
December 2024
Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, UP, 221005, India.
Background: Lymphatic Filariasis (LF) is a neglected tropical disease affecting more than 882 million people in 44 countries of the world. A multi-epitope prophylactic/therapeutic vaccination targeting filarial defense proteins would be invaluable to achieve the current LF elimination goal.
Method: Two groups of proteins, namely Anti-oxidant (AO) and Heat shock proteins (HSPs), have been implicated in the effective survival of the filarial parasites in their hosts.
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