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Radiation-Associated Angiosarcoma of the Breast: The State of the Art of a Rare and Aggressive Disease.
J Pers Med
August 2024
Pathology Unit, Azienda Sanitaria Locale, Ospedale San Giacomo, 15067 Novi Ligure, Italy.
Introduction: Considering the increasing number of conservative surgeries (quadrantectomies) for primary breast carcinoma, especially in the early stages, often followed by adjuvant radiotherapy, the incidence of radiation-associated angiosarcoma (RAS) is expected to rise in the coming decades, and it will represent a clinical and therapeutic challenge, as limited data are available due to the rarity and heterogeneity of the disease. Though the prognosis of these patients is poor, a number of clinical and pathological factors can be evaluated to better understand the course of RAS. The aim of this systematic review is to explore the available clinical-pathological, therapeutic, and prognostic data regarding RAS to evaluate its occurrence, diagnosis, treatment, and outcomes.
View Article and Find Full Text PDFEcthyma gangrenosum in pediatric patients: 10-year experience at the National Institute of Pediatrics.
Int J Dermatol
November 2023
Dermatology Department, Instituto Nacional de Pediatría, Mexico City, Mexico.
Article Synopsis
- - Ecthyma gangrenosum (EG) is a skin condition mainly caused by Pseudomonas aeruginosa infections in immunocompromised patients, presenting with reddish-purple spots that can progress quickly to severe skin ulcers.
- - A study analyzed 17 EG patients, revealing that many had underlying conditions like acute lymphoblastic leukemia; most presented with systemic symptoms like fever and pain, and P. aeruginosa was the most commonly isolated bacteria.
- - The findings suggest that if a patient shows fever and pain with rapidly worsening skin lesions, physicians should suspect EG and start treatment without waiting for lab results.
Fixed drug eruptions (FDEs) are dermatological manifestations of drug reactions that often occur in the same location upon re-exposure to a drug. They usually appear as erythematous-violaceous, circular patches, but several different variants have been described. They can often present without any associated symptoms, but in some cases, patients may complain of pain and pruritus.
View Article and Find Full Text PDFCutaneous manifestations associated with SARS-CoV-2: an emerging topic in a pandemic era.
BMJ Case Rep
September 2021
Internal Medicine, SESARAM, Funchal, Portugal.
A 70-year-old man was admitted to our COVID-19 ward with thoracalgia, productive mucus cough, fatigue and erythematous-violaceous macules on the inner side of feet and interdigital regions. The patient was started on oxygen and dexamethasone. On the day of discharge, he maintained the skin changes despite the resolution of COVID-19 symptoms.
View Article and Find Full Text PDFMultisystemic fusariosis with fulminant evolution.
An Bras Dermatol
November 2020
Department of Pathology, Pereira Rossell Hospital, Montevideo, Uruguay.
This report presents the case of a 13-year-old female patient with history of acute myeloid leukemia, who, after a bone marrow transplant, began to vomit and experienced rapidly progressive deterioration of consciousness, in addition to disseminated erythematous-violaceous macules, and some blisters with hemorrhagic content inside. Skin biopsy evidenced intravascular filamentous structures. A blood culture confirmed the presence of Fusarium oxysporum.
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