AI Article Synopsis
- Current immunosuppressive treatments have improved outcomes for autoimmune kidney diseases, but they increase the risk of serious infections, particularly cytomegalovirus (CMV).
- Two cases of renal vasculitis (GPA and MPA) are reported, where patients developed severe gastrointestinal CMV disease, leading to significant complications and one fatality.
- The review emphasizes the need for more research into the links between immunosuppression and CMV infections, highlighting the importance of evaluating antiviral prevention strategies for high-risk patients.
Article Abstract
Although the use of current immunosuppressive regimens has significantly improved the outcomes of autoimmune renal diseases, infectious complications remain an important clinical concern. Cytomegalovirus (CMV) infection has been shown to be one of the major causes of mortality in this group of patients. We report two cases of renal vasculitis (Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA)) that developed into severe gastrointestinal CMV disease and manifested with massive small bowel bleeding, resulting in an eventual fatal outcome for one of the patients. Risk factors, pathogenesis, role of immunosuppression in the development of CMV infection, and antiviral treatment are discussed in this review. These cases highlight the need for further research to evaluate the complex mechanisms between immunosuppression and CMV occurrence as well as the role of antiviral prophylaxis in high-risk patients undergoing immunosuppressive therapies. .
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| http://dx.doi.org/10.5414/CN108811 | DOI Listing |
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