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Splicing factor SRSF1 attenuates cardiomyocytes apoptosis via regulating alternative splicing of Bcl2L12.
Cell Biosci
November 2024
Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Jinan University, Zhuhai, 519000, Guangdong, China.
Background: Aberrant alternative splicing (AS) events, triggered by the alterations in serine/arginine splicing factor 1 (SRSF1), a member of the SR protein family, have been implicated in various pathological processes. However, the function and mechanism of SRSF1 in cardiovascular diseases remain unclear.
Results: In this study, we found that the expression of SRSF1 was significantly down-regulated in the hearts of mice with acute myocardial infarction (AMI) and H9C2 cells exposed to HO.
Bcl2l12, a novel protein interacting with Arf6, triggers Schwann cell differentiation programme.
J Biochem
January 2025
Laboratory of Molecular Neurology, Department of Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan.
Schwann cells are glial cells in the peripheral nervous system (PNS); they wrap neuronal axons with their differentiated plasma membranes called myelin sheaths. Although the physiological functions, such as generating saltatory conduction, have been well studied in the PNS, the molecular mechanisms by which Schwann cells undergo their differentiation programme without apparent morphological changes before dynamic myelin sheath formation remain unclear. Here, for the first time, we report that Arf6, a small GTP/GDP-binding protein controlling morphological differentiation, and the guanine-nucleotide exchange factors cytohesin proteins are involved in the regulation of Schwann cell differentiation marker expression in primary Schwann cells.
View Article and Find Full Text PDFAlternative splicing in ovarian cancer.
Cell Commun Signal
October 2024
HIM-BGI Omics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310030, China.
Ovarian cancer is the second leading cause of gynecologic cancer death worldwide, with only 20% of cases detected early due to its elusive nature, limiting successful treatment. Most deaths occur from the disease progressing to advanced stages. Despite advances in chemo- and immunotherapy, the 5-year survival remains below 50% due to high recurrence and chemoresistance.
View Article and Find Full Text PDFQuercetin ameliorates lupus symptoms by promoting the apoptosis of senescent Tfh cells via the Bcl-2 pathway.
Immun Ageing
October 2024
Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, 139 Middle Renmin Road, Changsha, Hunan, 410011, China.
Systemic lupus erythematosus (SLE) is an autoimmune disorder that commonly affects the skin, kidneys, joints, and various other systemic tissues, with its development intricately linked to the process of immunosenescence. Quercetin (QC), a phytochemical that occurs naturally, demonstrates many different biological capabilities, such as antibacterial, antioxidant, and anti-inflammatory activities. Our investigation found that QC effectively reduced kidney damage and relieved mesenteric lymph nodes (mLNs) swelling in MRL/lpr lupus mice.
View Article and Find Full Text PDFComprehensive Analysis of lncRNA and mRNA Expression Profile of Macrophage RAW264.7 Stimulated by Antimicrobial Peptide BSN-37.
Protein Pept Lett
November 2023
College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.
Article Synopsis
- BSN-37 is a novel antimicrobial peptide isolated from bovine spleen that shows antibacterial and immunomodulatory properties, prompting a study on its effects on mouse macrophages RAW264.7.
- The research involved using a whole gene expression microarray to identify differentially expressed lncRNAs and mRNAs following BSN-37 treatment, leading to the selection of eight lncRNAs and nine mRNAs for further validation through qRT-PCR.
- Results revealed significant changes, with 1294 lncRNAs and 260 mRNAs differing between treated and control groups, highlighting genes tied to immune responses, cell growth, and metabolism, and confirming the reliability of the data through qRT-PCR validation.
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