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Eczema Herpeticum: A Fatal Rash That Mimics Many.
S D Med
September 2024
Avera Medical Group Infectious Disease Specialists, Sioux Falls, South Dakota.
Eczema herpeticum (EH) is a potentially life-threatening condition, especially in the pediatric population, that occurs among patients with atopic dermatitis (AD). AD is a chronic inflammatory skin disorder with a complex pathophysiology that predisposes patients to EH. Herpes simplex virus (HSV) 1 is implicated in 90 % of EH cases and often initially presents with gingivostomatitis.
View Article and Find Full Text PDFVirus-Induced Voracity: Uncovering Hyperphagia Post-Herpes Simplex Virus Type 1.
Case Rep Neurol
October 2024
Department of Neurology, Institute of Medical Sciences Banaras Hindu University, Varanasi, India.
Article Synopsis
- HSV-1 is a major cause of fatal encephalitis, often presenting with symptoms like fever, headache, seizures, and focal neurological deficits; hyperphagia, an increased appetite, is a rare complication.
- A 25-year-old woman with a history of meningitis experienced severe neurological symptoms, MRI showed abnormalities in her temporal lobes, and CSF analysis confirmed an HSV-1 infection, leading to treatment with acyclovir.
- The case illustrates that hyperphagia can occur as a standalone symptom of HSV encephalitis, highlighting the need for specialized treatment approaches and the importance of early diagnosis to avoid serious complications.
HSV-1 encephalitis (HSE) is the most common cause of fatal sporadic encephalitis in the United States. HSE in adults is most commonly due to the reactivation of HSV in the central nervous system (CNS) which results in CNS necrosis leading to neurological compromise. The most common symptoms include altered mentation, fever, seizures, and focal neurological deficits.
View Article and Find Full Text PDFHigh silent prevalence of human herpesvirus 1 (HSV-1) infection affecting the indigenous reservation of the municipality of Dourados, Central-West Brazil.
BMC Infect Dis
July 2024
Molecular Virology and Parasitology Laboratory, Oswaldo Cruz Foundation, Rio de Janeiro, 21040360, Brazil.
Article Synopsis
- * A cross-sectional approach was used, enrolling 1,138 individuals over nearly two years, with tests revealing a 20% prevalence of IgM antibodies and a remarkable 97.5% for IgG antibodies against HSV-1.
- * The presence of HSV-1 DNA was confirmed in over a quarter of individuals with positive IgM results, indicating a significant silent prevalence of the virus within this community, particularly in individuals with certain urinary and genital symptoms.
Open-label, phase II study of talimogene laherparepvec plus pembrolizumab for the treatment of advanced melanoma that progressed on prior anti-PD-1 therapy: MASTERKEY-115.
Eur J Cancer
August 2024
UofL Health - Brown Cancer Center, University of Louisville, Louisville, KY, USA. Electronic address:
Background: Treatment options for immunotherapy-refractory melanoma are an unmet need. The MASTERKEY-115 phase II, open-label, multicenter trial evaluated talimogene laherparepvec (T-VEC) plus pembrolizumab in advanced melanoma that progressed on prior programmed cell death protein-1 (PD-1) inhibitors.
Methods: Cohorts 1 and 2 comprised patients (unresectable/metastatic melanoma) who had primary or acquired resistance, respectively, and disease progression within 12 weeks of their last anti-PD-1 dose.
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