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An Epigenetics-Inspired DNA-Based Data Storage System. | LitMetric

An Epigenetics-Inspired DNA-Based Data Storage System.

Angew Chem Int Ed Engl

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

Published: September 2016

Biopolymers are an attractive alternative to store and circulate information. DNA, for example, combines remarkable longevity with high data storage densities and has been demonstrated as a means for preserving digital information. Inspired by the dynamic, biological regulation of (epi)genetic information, we herein present how binary data can undergo controlled changes when encoded in synthetic DNA strands. By exploiting differential kinetics of hydrolytic deamination reactions of cytosine and its naturally occurring derivatives, we demonstrate how multiple layers of information can be stored in a single DNA template. Moreover, we show that controlled redox reactions allow for interconversion of these DNA-encoded layers of information. Overall, such interlacing of multiple messages on synthetic DNA libraries showcases the potential of chemical reactions to manipulate digital information on (bio)polymers.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113786PMC
http://dx.doi.org/10.1002/anie.201605531DOI Listing

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