Fluorescent vinblastine probes for live cell imaging.

Chem Commun (Camb)

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA. and Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.

Published: August 2016

Herein we describe the synthesis of several fluorescent analogues of the clinically approved microtubule destabilizing agent vinblastine. The evaluated probes are the most potent described and provides the first example of uptake, distribution and live cell imaging using this well known antimitotic agent.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970878PMC
http://dx.doi.org/10.1039/c6cc04129aDOI Listing

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