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Double-Faced Immunological Effects of CDK4/6 Inhibitors on Cancer Treatment: Challenges and Perspectives.
Bioengineering (Basel)
October 2024
Department of Public Health, Zhejiang University School of Medicine, Hangzhou 310058, China.
Cyclin-dependent kinases (CDKs) are generally involved in the progression of cell cycle and cell division in normal cells, while abnormal activations of CDKs are deemed to be a driving force for accelerating cell proliferation and tumorigenesis. Therefore, CDKs have become ideal therapeutic targets for cancer treatment. The U.
View Article and Find Full Text PDFDNA repair and anti-cancer mechanisms in the long-lived bowhead whale.
bioRxiv
November 2024
Department of Biology, University of Rochester, Rochester, NY, USA.
At over 200 years, the maximum lifespan of the bowhead whale exceeds that of all other mammals. The bowhead is also the second-largest animal on Earth, reaching over 80,000 kg. Despite its very large number of cells and long lifespan, the bowhead is not highly cancer-prone, an incongruity termed Peto's Paradox.
View Article and Find Full Text PDFTherapeutic BCG vaccine protects against long COVID: The BATTLE randomized clinical trial.
J Intern Med
January 2025
UroScience, State University of Campinas, Unicamp, Campinas, São Paulo, Brazil.
Background: Bacillus Calmette-Guérin (BCG) injected during the COVID-19 convalescence period was safe and enhanced recovery from anosmia and dysgeusia in the acute phase.
Objectives: To report the long-term results of the BATTLE trial, BCG vaccine in adults with mild COVID-19.
Methods: Design: Double-blind, placebo-controlled, randomized (1:1) clinical trial.
Autonomous Fontan pump: Computational feasibility study.
JTCVS Open
October 2024
Mechanical Solutions Inc, Whippany, NJ.
Objective: After Fontan palliation, patients with single-ventricle physiology are committed to chronic circulatory inefficiency for the duration of their lives. This is due in large part to the lack of a subpulmonary ventricle. A low-pressure rise cavopulmonary assist device can address the subpulmonary deficit and offset the Fontan paradox.
View Article and Find Full Text PDFGlobal impacts of peroxisome and pexophagy dysfunction revealed through multi-omics analyses of lon2 and atg2 mutants.
Plant J
December 2024
Department of Biosciences, Rice University, Houston, Texas, 77005, USA.
Peroxisomes house diverse metabolic pathways that are essential for plant and animal survival, including enzymes that produce or inactivate toxic byproducts. Despite the importance of peroxisomes and their collaborations with other organelles, the mechanisms that trigger or prevent peroxisome turnover and the cellular impacts of impaired peroxisomes are incompletely understood. When Arabidopsis thaliana LON2, a peroxisomal protein with chaperone and protease capacity, is disrupted, metabolic dysfunction and protein instability in peroxisomes ensue.
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