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Co-Administration of Vitamin U and Antacids in Diets Relieves Gastric Ulcers in Finishing Pigs.
J Anim Physiol Anim Nutr (Berl)
November 2024
Department of Animal Biotechnology, Dankook University, Cheonan, Republic of Korea.
One hundred and forty [(Landrace × Yorkshire) × Duroc] barrows and gilts (86.5 ± 1.5 kg) were used in a 28-day experiment in a randomised complete block design.
View Article and Find Full Text PDFLiquid-liquid phase transition as a basis for novel materials for skin repair and regeneration.
J Mater Chem B
October 2024
ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, Germany.
Inorganic materials are of increasing interest not only for bone repair but also for other applications in regenerative medicine. In this study, the combined effects of energy-providing, regeneratively active inorganic polyphosphate (polyP) and also morphogenetically active pearl powder on wound healing were investigated. Aragonite, the mineralic constituent of pearl nacre and thermodynamically unstable form of crystalline calcium carbonate, was found to be converted into a soluble state in the presence of a Ca-containing wound exudate, particularly upon addition of sodium polyP (Na-polyP), driven by the transfer of Ca ions from aragonite to polyP, leading to liquid-liquid phase separation to form an aqueous Ca-polyP coacervate.
View Article and Find Full Text PDFProton pump inhibitors and cancer treatments: Emerging evidence against coadministration.
Cancer Treat Rev
September 2024
School of Pharmacy, University of Washington, Seattle, USA. Electronic address:
Background: Proton pump inhibitors (PPIs) are widely used in cancer patients despite accumulating data showing that they can impact the efficacy of major anticancer drugs. This is particularly important with tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (CPIs).
Results: Most TKIs require gastric acidity for their absorption and some retrospective series demonstrated that coprescription decreases the survival benefit of some TKI use (erlotinib, gefitinib and pazopanib).
Effect of Food, Crushing of Tablets, and Antacid Coadministration on Maribavir Pharmacokinetics in Healthy Adult Participants: Results From 2 Phase 1, Open-Label, Randomized, Crossover Studies.
Clin Pharmacol Drug Dev
June 2024
Quantitative Clinical Pharmacology, Takeda Development Center Americas, Inc., Cambridge, MA, USA.
The effect of food composition, tablet crushing, and antacid coadministration on maribavir pharmacokinetics was assessed in 2 Phase 1 studies in healthy adults. In the first, a single maribavir 400-mg dose was administered under fasting conditions, with a low-fat/low-calorie or a high-fat/high-calorie meal. In the second, a single maribavir 100-mg dose was administered under fasting conditions, as a crushed tablet, or as a whole tablet alone or with an antacid.
View Article and Find Full Text PDFPharmacokinetic Interactions Between Tegoprazan and the Combination of Clarithromycin, Amoxicillin and Bismuth in Healthy Chinese Subjects: An Open-Label, Single-Center, Multiple-Dosage, Self-Controlled, Phase I Trial.
Clin Drug Investig
May 2024
Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan, 430022, Hubei, China.
Background: Tegoprazan is a potassium-competitive acid blocker that inhibits gastric acid and which may be used for eradicating Helicobacter pylori. This study focuses on the pharmacokinetic interaction and safety between tegoprazan and the combination of clarithromycin, amoxicillin and bismuth in healthy Chinese subjects.
Methods: An open-label, three-period, single-center, multiple-dosage, single-sequence, phase I trial was conducted in 22 healthy subjects.
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