AI Article Synopsis
- Increased interest in using medications like d-cycloserine to enhance cognitive behavior therapy for anxiety, despite mixed evidence in human studies.
- An experiment with 54 participants tested if a single dose of d-cycloserine improved motor learning, comparing it to a placebo.
- Results showed no speed increase in motor learning; however, participants using d-cycloserine tended to make more careful, accurate responses, indicating no benefits for psychological treatments related to motor learning.
Article Abstract
Rationale: There has recently been increasing interest in pharmacological manipulations that could potentially enhance exposure-based cognitive behaviour therapy for anxiety disorders. One such medication is the partial NMDA agonist d-cycloserine. It has been suggested that d-cycloserine enhances cognitive behaviour therapy by making learning faster. While animal studies have supported this view of the drug accelerating learning, evidence in human studies has been mixed. We therefore designed an experiment to measure the effects of d-cycloserine on human motor learning.
Methods: Fifty-four healthy human volunteers were randomly assigned to a single dose of 250mg d-cycloserine versus placebo in a double-blind design. They then performed a motor sequence learning task.
Results: D-cycloserine did not increase the speed of motor learning or the overall amount learnt. However, we noted that participants on d-cycloserine tended to respond more carefully (shifting towards slower, but more correct responses).
Conclusion: The results suggest that d-cycloserine does not exert beneficial effects on psychological treatments via mechanisms involved in motor learning. Further studies are needed to clarify the influence on other cognitive mechanisms.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066480 | PMC |
| http://dx.doi.org/10.1177/0269881116658988 | DOI Listing |
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