Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.thromres.2016.07.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Population pharmacokinetic study of the effect of polymorphisms in the ABCB1 and CES1 genes on the pharmacokinetics of dabigatran.
Front Pharmacol
November 2024
Clinical Trials Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Article Synopsis
- This study aimed to evaluate how genetic variations in the ABCB1 and CES1 genes affect dabigatran plasma concentrations in healthy Chinese subjects using a population pharmacokinetic (PopPK) approach.
- A total of 1,926 pharmacokinetic samples from 123 individuals taking 150 mg of dabigatran were analyzed, revealing that food intake and the ABCB1 SNP rs4148738 significantly influenced drug absorption and clearance.
- The PopPK model effectively described the pharmacokinetics of dabigatran, indicating that both genetic factors and food consumption can affect how the drug is processed in the body.
Lung cancer, platinum analog-based frontline treatment and pharmacogenetic limitations.
Per Med
December 2024
Faculty of Biology, Kabul University, Afghanistan.
Article Synopsis
- - Lung cancer is the most lethal type of cancer worldwide, and the main treatment, cisplatin, often leads to rapid resistance and severe side effects like hearing loss and kidney damage.
- - This review focuses on the link between specific gene variations (single nucleotide polymorphisms or SNPs) and the toxicity caused by cisplatin.
- - The authors suggest using knowledge about these genetic variations to reduce the chances of treatment failure and minimize harmful side effects from cisplatin.
Pharmacogenomic Study of Selected Genes Affecting Amlodipine Blood Pressure Response in Patients with Hypertension.
Pharmgenomics Pers Med
October 2024
Department of Biology, Faculty of Science, University of Moncton, Moncton, NB, E1A 3E9, Canada.
Introduction: Despite the availability of various antihypertensive medications, the response to these medications varies among individuals. Understanding how individual genetic variations affect drugs treatment outcomes is a key area of focus in precision medicine. This study investigated the correlation between single nucleotide polymorphisms (SNPs) in selected genes (CACNA1C, CACNA1D, ABCB1, ACE, ADBR2, and NOS1AP) and the blood pressure (BP) control by amlodipine.
View Article and Find Full Text PDFAn accurate haplotyping method using multiplex pyrosequencing with AS-PCR to detect ABCB1 haplotypes associated with rivaroxaban-derived hemorrhagic events.
Talanta
January 2025
School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China; Department of Clinical Pharmacy, Jinling Hospital, Nanjing, 210002, China. Electronic address:
In clinical practice, owing to the comprehensive genetic insights they offer, haplotypes have attracted greater attention than individual single nucleotide polymorphisms (SNPs). Due to the long distances across SNP locations, detecting the haplotype using genomic DNA is challenging. Current haplotyping methods are either expensive and labor-intensive (high-throughput DNA sequencing), or haplotyping a single clinical sample (computational approach) is impossible.
View Article and Find Full Text PDFPrecision Medicine in Childhood Cancer: The Influence of Genetic Polymorphisms on Vincristine-Induced Peripheral Neuropathy.
Int J Mol Sci
August 2024
Pharmacogenetics Unit, Pharmacy Service, University Hospital Virgen de las Nieves, Avda. de las Fuerzas Armadas 2, 18004 Granada, Spain.
Cancer is the leading cause of disease-related death among children. Vincristine (VCR), a key component of childhood cancer treatment protocols, is associated with the risk of peripheral neuropathy (PN), a condition that may be reversible upon drug discontinuation but can also leave lasting sequelae. Single nucleotide polymorphism (SNP) in genes involved in VCR pharmacokinetics and pharmacodynamics have been investigated in relation to an increased risk of PN.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!