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Background And Aims: Honey has long been studied for its healing abilities in wound care. This narrative review examines its properties and their impact on wound healing, particularly its ability to accelerate wound closure and promote tissue regeneration. The review focuses on how honey's botanical origins affect its medical properties and wound-healing capabilities.
View Article and Find Full Text PDFTheoretical study of the formation of HO by lytic polysaccharide monooxygenases: the reaction mechanism depends on the type of reductant.
Chem Sci
January 2025
State Key Laboratory of Physical Chemistry of Solid Surfaces and Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry College of Chemistry and Chemical Engineering, Xiamen University Xiamen 361005 China
Lytic polysaccharide monooxygenases (LPMOs) are a unique group of monocopper enzymes that exhibit remarkable ability to catalyze the oxidative cleavage of recalcitrant carbohydrate substrates, such as cellulose and chitin, by utilizing O or HO as the oxygen source. One of the key challenges in understanding the catalytic mechanism of LPMOs lies in deciphering how they activate dioxygen using diverse reductants. To shed light on this intricate process, we conducted in-depth investigations using quantum mechanical/molecular mechanical (QM/MM) metadynamics simulations, molecular dynamics (MD) simulations, and density functional theory (DFT) calculations.
View Article and Find Full Text PDFElectrical Contacts to Graphene by Postgrowth Patterning of Cu Foil for the Low-Cost Scalable Production of Graphene-Based Flexible Electronics.
ACS Omega
January 2025
Department of Electronics Engineering, Chungnam National University, Daejeon 34134, Republic of Korea.
Numerous studies have focused on graphene owing to its potential as a next-generation electronic material, considering its high conductivity, transparency, superior mechanical stiffness, and flexibility. However, cost-effective mass production of graphene-based electronics based on existing fabrication methods, such as graphene transfer and metal formation, remains a challenge. This study proposes a simple and efficient method for creating electrical contacts with graphene.
View Article and Find Full Text PDFAdvancing precision psychiatry and targeted treatments: Insights from immunopsychiatry.
Brain Behav Immun
January 2025
Univ Paris Est Créteil, INSERM U955, IMRB, Translational NeuroPsychiatry Laboratory, Fondation FondaMental, Créteil, France. Electronic address:
Despite tremendous advancements in neuroscience, there has been limited impact on patient care. Current psychiatric treatments are largely non-specific, and drug development is hindered by outdated, overinclusive diagnostic categories and a "one-size-fits-all" approach. Additionally, mechanisms underlying psychiatric illnesses and their treatments with conventional medications remain poorly understood.
View Article and Find Full Text PDFThe natural product-derived JM-9 alleviates high-fat diet-induced fatty liver in mice by targeting MD2.
Int Immunopharmacol
January 2025
Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035 Zhejiang, China; The Affiliated Cangnan Hospital and Chemical Biology Research Center, Wenzhou Medical University, Wenzhou 325035 Zhejiang, China. Electronic address:
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD), is gradually emerging as one of the most prevalent liver diseases worldwide. Previous research demonstrated the involvement of myeloid differentiation factor 2 (MD2), a co-receptor of TLR4, as a key mediator in MASLD pathogenesis. The current study identifies JM-9 as a novel MD2 inhibitor, and focuses on evaluating its potential therapeutic effects in mitigating MASLD progression.
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