The continuation of cancer chemotherapy was examined from the view point of the patient's economic burden and the national finance. Along with the rapid technological progress, anti-cancer drugs become more and more expensive. According to our survey, not a little patient was obliged to give up the most appropriate treatment due to some economic reasons. The impact of the increasing cost of cancer treatment and the rational measure to minimize the patient's burden were discussed. The mean out-of-pocket expense of the patients without economic worries was three-fourths that of the patients with economic worries. In other words, if the economic burden is reduced by around a quarter in the patients whose burden is heavy, they would certainly receive optimal medical care. As for the situation in which the cancer chemotherapy have to be interrupted due to the constraint of limited funding, it seemed difficult to continue to avoid this thoroughly in the future without the drastic reform of medical insurance system. The importance to set priorities and allocate human and financial resources within the financial crunch was discussed while making reference to health care reforms of several western countries in the late 1990's.
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Phys Rev Lett
December 2024
Department of Physics, Brock University, St. Catharines, Ontario L2S 3A1, Canada.
Based on its simple valence electron configuration, we may expect lithium to have straightforward physical properties that are easily explained. However, solid lithium, when cooled below 77 K, develops a complex structure that has been debated for decades. A close parallel is found in sodium below 36 K where the crystal structure still remains unresolved.
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December 2024
University of Virginia, Charlottesville, VA, USA.
Background: The microvasculature of the central nervous system (CNS), which delivers oxygen and nutrients and forms a critical barrier protecting the CNS, is deleteriously affected by both Alzheimer's Disease (AD) and Type 2 Diabetes (T2D). Previous studies have shown pericyte dropout and vessel constriction in brain capillaries in AD, while other studies have shown pericyte bridging and dropout in retinal capillaries in T2D. T2D patients have increased risk of AD, suggesting potentially related microvascular pathological mechanisms.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
PCM Consulting, Pathways Connectivity Maps Inc., Mountain View, CA, USA.
Background: High-throughput assays have attracted significant attention in Alzheimer's Disease (AD) research, especially for enabling rapid diagnostics screening for factors at the molecular level contributing to the disease recurrence. With advances in laboratory automation, there is a growing need for quality pre-clinical data. Assays such as Microarrays, Proteomics, or AI are all dependent on high-quality input data that serve as a starting point.
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December 2024
The Jackson Laboratory, Bar Harbor, ME, USA.
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