AI Article Synopsis
- * High-throughput sequencing revealed that blaGES-5 is located on a 28.5-kb nonconjugative plasmid named pGES-GZ, which contains a 13-kb plasmid backbone similar to those from other Gram-negative bacteria.
- * Found a novel class 1 integron on pGES-GZ with a gene cassette containing orf28 and blaGES-5, where orf28 may be linked to resistance against fosfomycin.
Article Abstract
Klebsiella pneumoniae strain KP01 carrying blaGES-5 was identified from a patient in Guangzhou, China. High-throughput sequencing assigned blaGES-5 to a 28.5-kb nonconjugative plasmid, pGES-GZ. A 13-kb plasmid backbone sequence on pGES-GZ was found to share high sequence identities with plasmids from Gram-negative nonfermenters. A novel class 1 integron carrying a gene cassette array of orf28-orf28-blaGES-5 was identified on pGES-GZ, within which orf28 encoded a hypothetical protein possibly correlated to fosfomycin resistance.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038298 | PMC |
| http://dx.doi.org/10.1128/AAC.00764-16 | DOI Listing |
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