AI Article Synopsis
- The JAK2-V617F mutation is the most common genetic disorder linked to chronic myeloproliferative neoplasms in patients.
- A study was conducted on 101 patients to identify risk factors for thrombosis in essential thrombocytosis and polycythemia vera.
- Results showed that venous thrombosis before diagnosis was notably higher in JAK2 positive patients, while after diagnosis, risk was similar across both JAK2 positive and negative groups, significantly increasing in elderly patients.
Article Abstract
The most common genetic disorder in Philadelphia negative chronic myeloproliferative neoplasms is the JAK2-V617F mutation. In the present study, we aimed to determine risk factors for thrombosis in patients with essential thrombocytosis and polycythemia vera. We screened the medical records of 101 patients. Risk factors which may predict thrombosis were recorded. Venous thrombosis (VT) before diagnosis was significantly higher in JAK2 positive patients. VT after diagnosis was similar in JAK2 positive and negative groups, and was significantly higher in elderly patients. Treatment places importance on the JAK2 mutation under unmodifiable cardiovascular risk factors such as advanced age after diagnosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930758 | PMC |
| http://dx.doi.org/10.1007/s12288-015-0578-2 | DOI Listing |
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