AI Article Synopsis
- The COG complex is crucial for managing vesicle trafficking to and inside the Golgi apparatus in yeast (Saccharomyces cerevisiae).
- Using negative-stain electron microscopy, the study reveals the unique structure of the COG complex, which consists of eight subunits with a flexible, complex shape.
- This distinctive architecture, featuring four or five flexible legs, suggests that the COG complex is effectively designed for capturing and merging vesicles.
Article Abstract
The conserved oligomeric Golgi (COG) complex orchestrates vesicular trafficking to and within the Golgi apparatus. Here, we use negative-stain electron microscopy to elucidate the architecture of the hetero-octameric COG complex from Saccharomyces cerevisiae. Intact COG has an intricate shape, with four (or possibly five) flexible legs, that differs strikingly from that of the exocyst complex and appears to be well suited for vesicle capture and fusion.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972656 | PMC |
| http://dx.doi.org/10.1038/nsmb.3263 | DOI Listing |
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