AI Article Synopsis
- The text outlines the process of synthesizing and ensuring the quality of the radiotracer [(18) F]T807, which is used for imaging tau protein aggregates.
- The synthesis takes about 48 minutes, achieving a high specific activity of over 4.4 TBq/µmole and a radiochemical yield of 32%.
- All production standards set by the US Pharmacopeia Chapter <823> were met during the quality control phase.
Article Abstract
The detailed synthesis and quality control of [(18) F]T807, radiotracer for tau protein aggregate imaging, are described. The radiotracer synthesis was accomplished in an average of 48 min with an average specific activity at end-of-synthesis of over 4.4 TBq/µmole (120 Ci/µmole) and an average radiochemical yield of 32%. Compliance with all standard US Pharmacopeia Chapter <823> acceptance tests was observed.
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| http://dx.doi.org/10.1002/jlcr.3425 | DOI Listing |
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