Light and electron microscopies were applied to examine liver punctates from 10 patients with typhoid fever. Both in the full swing of the disease and in clinical recovery (convalescence), dystrophic and necrobiotic changes along with focal cell death were found to occur in the hepatocytes, endothelial and Kupffer cells covering the sinuses. The protein-synthesizing system and mitochondria were demonstrated to be primarily destroyed. The microbes of typhoid fever were located in the hepatocytes, endothelial and Kupffer cells.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Melioidosis - An under-recognized dreaded disease in Southeast Asia.
Turk J Emerg Med
January 2025
Department of Emergency Medicine and Trauma, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Melioidosis is a disease endemic to India but often goes unrecognized, leading to considerable illness and death. We present the case of a 31-year-old man who had a fever of unknown origin, abnormal renal and liver function tests, and negative tests for dengue, typhoid, leptospirosis, and scrub typhus. Imaging revealed multiple splenic infarcts.
View Article and Find Full Text PDF[Pathology of the spleen : Differential diagnosis of splenomegaly].
Pathologie (Heidelb)
January 2025
Institut für Pathologie, Universitätsmedizin Göttingen, Universität Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland.
After describing the anatomy of the spleen and the most important immunohistochemical stains for identifying cellular constituents of the normal splenic compartments, etiologies of splenomegaly and the diagnostic approach for spleen biopsies are discussed using the example of a North African patient with a recent migration background and sudden fever. The focus is on infectious diseases and the morphology and molecular features of hematolymphoid neoplasms, particularly the primary "splenic B‑cell lymphomas" according to the World Health Organization (WHO) classification. The importance of clinicopathological correlations and interdisciplinary cooperation in splenic pathology is emphasized.
View Article and Find Full Text PDFA systematic review of recent outbreaks and the efficacy and safety of drugs approved for the treatment of infections.
IJID Reg
March 2025
Department of Pharmacy Practice, School of Pharmacy, IMU University, Kuala Lumpur, Malaysia.
A systematic review was conducted to critically analyze the outbreaks, efficacy, and safety of drugs used to treat various infections. Four drugs-azithromycin, ceftriaxone, ciprofloxacin, and amoxicillin-are commonly used to treat infections, and all four drugs were included in this review. This review found that, of these, azithromycin and ceftriaxone were more effective in treating infections based on the patient's length of stay in the hospital and the rate at which the fever was resolved.
View Article and Find Full Text PDFLive Typhoid and Yellow Fever Vaccines Administered to a Patient With Ulcerative Colitis on Vedolizumab.
ACG Case Rep J
October 2024
Department of Medicine, Division of Gastroenterology and Hepatology, School of Medicine & Public Health, University of Wisconsin-Madison, Madison, WI.
Patients with inflammatory bowel disease who receive immunosuppressive therapy have an increased risk of infection. Live vaccines are contraindicated in these patients because of the increased risk of unchecked replication of the attenuated vaccine microorganisms. Vedolizumab is a gut-selective biological agent with a low risk of infection approved for the treatment of inflammatory bowel disease.
View Article and Find Full Text PDFFoodborne Infections and : Current Primary Prevention Tools and Future Perspectives.
Vaccines (Basel)
December 2024
Food Hygiene and Nutrition Service, Local Health Unit 3, Department of Prevention, 16142 Genoa, Italy.
is considered the major zoonotic and foodborne pathogen responsible for human infections. It includes the serovars causing typhoid fever ( and ) and the non-typhoidal salmonella (NTS) serovars ( and ), causing enteric infections known as "Salmonellosis". NTS represents a major public health burden worldwide.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!