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| http://dx.doi.org/10.1016/j.ijid.2016.07.008 | DOI Listing |
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Clinical characteristics and aetiological analysis of combined central and pulmonary cryptococcal infection: Clinical cases.
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Zhongshan Hospital, Fudan University, Shanghai, China.
This paper presents a summary of seven cases of combined pulmonary and central cryptococcal infection and analyses of their clinical features, treatment and prognosis. No clear correlation was identified between the intracranial cryptococcal capsular antigen titre and either the intracranial pressure or the amount of protein in the cerebrospinal fluid. Pulmonary lesions may develop in any of the lung lobes and manifest in multiple forms.
View Article and Find Full Text PDFMachine learning-driven in-hospital mortality prediction in HIV/AIDS patients with infection: a single-centred retrospective study.
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Guangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning, Guangxi, PR China.
() is a widely disseminated betaherpesvirus that typically induces latant infections. In immunocompromised populations, especially transplant and HIV-infected patients, infection increases in-hospital mortality. Although machine learning models have been widely used in clinical diagnosis and prognosis prediction, reports on machine learning model predictions for the in-hospital mortality of HIV/AIDS patients with infection have not been reported.
View Article and Find Full Text PDFConcurrent Primary Cutaneous Cryptococcosis and Bowen's Disease in a Patient With Multiple Sclerosis on Fingolimod: A Rare Case Report and Review of Literature.
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View Article and Find Full Text PDFCryptococcal invasion: a comprehensive case of adrenal and systemic infection amid immunosuppression.
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Department of Urology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Jixi Road 218, Shushan District, Hefei, Anhui, 230022, China.
Article Synopsis
- - The case report discusses a patient with disseminated cryptococcosis, a rare fungal infection affecting the lungs and central nervous system, complicated by meningitis and pneumonia, along with unusual adrenal involvement.
- - This patient was immunosuppressed due to primary myelofibrosis and Ruxolitinib treatment, showing significant findings in imaging scans that led to the discovery of adrenal cryptococcosis through surgical intervention and pathology.
- - After a month of oral antifungal treatment, including amphotericin B and other medications, the patient showed improved outcomes with reduced antigen levels and no signs of recurrence during follow-up visits.
IL-6 deficiency accelerates cerebral cryptococcosis and alters glial cell responses.
J Neuroinflammation
September 2024
Department of Oral Biology, University of Florida College of Dentistry, 1395 Center Drive, DG-48, P.O. Box 100424, Gainesville, FL, 32610, USA.
Article Synopsis
- Cryptococcus neoformans (Cn) is a dangerous fungus that can lead to severe brain infections, especially in people with weakened immune systems; the study explores the role of the cytokine IL-6 in fighting this infection.* -
- Mice lacking IL-6 (knock-out) showed increased mortality and higher fungal levels in the brain and blood compared to wild-type and IL-6 supplemented groups, indicating IL-6's importance in controlling Cn infection.* -
- The presence of IL-6 led to a stronger immune response in the brain, characterized by activated microglia that help fight off the fungus, while its absence resulted in fewer defensive responses and potential neurodegeneration.*
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