Three β,γ-modified α-l-threofuranosyl nucleoside triphosphates were synthesized. The β,γ-modified tTTPs undergo a single incorporation event with HIV RT but undergo multiple incorporations to form full-length product with engineered thermophilic polymerases.
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| http://dx.doi.org/10.1016/j.bmcl.2016.07.008 | DOI Listing |
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