AI Article Synopsis
- - The study explores thermoresponsive mesoporous silica nanoparticles (MSNs) as innovative carriers for delivering quercetin (an antioxidant) to the skin, highlighting their ability to maintain the integrity of the drug and target specific areas.
- - Two types of MSNs were developed—one with a smaller pore size (3.5nm) and the other with a larger pore size (5.0nm)—by incorporating copolymers through a process called free radical copolymerization.
- - Characterization showed that both types of MSNs are biocompatible, and the larger pore size complex (Q/copoly-MSNbig) demonstrated better thermoresponsive properties, indicating its potential for advanced skin delivery applications
Article Abstract
Recently, mesoporous silica nanoparticles (MSNs) have emerged as promising drug delivery systems able to preserve the integrity of the carried substance and/or to selectively reach a target site; however, they have rarely been explored for skin application. In this study, thermoresponsive MSNs, designed to work at physiologic cutaneous temperature, are proposed as innovative topical carriers for quercetin (Q), a well-known antioxidant. The thermosensitive nanoparticles were prepared by functionalizing two different types of matrices, with pore size of 3.5nm (MSNsmall) and 5.0nm (MSNbig), carrying out a free radical copolymerization of N-isopropylacrylamide (NIPAM) and 3-(methacryloxypropyl)trimethoxysilane (MPS) inside the mesopores. The obtained copolymer-grafted MSNs (copoly-MSNs) were physico-chemically characterized and their biocompatibility was attested on a human keratinocyte cell line (HaCaT). The release profiles were assessed and the functional activity of Q, free or loaded, was evaluated in terms of antiradical and metal chelating activities. Ex vivo accumulation and permeation through porcine skin were also investigated. The characterization confirmed the copolymer functionalization of the MSNs. In addition, both the bare and functionalized silica matrices were found to be biocompatible. Among the copolymer-grafted complexes, Q/copoly-MSNbig exhibited more evident thermoresponsive behavior proving the potential of these thermosensitive systems for advanced dermal delivery.
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| http://dx.doi.org/10.1016/j.ijpharm.2016.07.024 | DOI Listing |
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