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Dorsal penile nerve block complicated by local anaesthetic systemic toxicity.
Urol Case Rep
January 2025
Department of Urology, Flinders Medical Centre, Adelaide, Australia.
A 39-year-old man presented with priapism. To facilitate corporal cavernosal aspiration, a dorsal penile nerve block was performed. A dose of 2000mg lignocaine was administered, instead of the intended 200mg.
View Article and Find Full Text PDFUntargeted metabolomics analysis of glycerophospholipid metabolism in very low birth weight infants administered multiple oil lipid emulsions.
BMC Pediatr
December 2024
Department of Intensive Care Unit, Hangzhou Women's Hospital, Hangzhou, 310016, Zhejiang, China.
Background: To compare the impact of two different lipid emulsions, specifically a soybean oil-based emulsion and a multiple oil emulsion (soybean oil, medium-chain triglycerides, olive oil, and fish oil, SMOF), on serum metabolites of very low birth weight (VLBW) infants using untargeted metabolomics analysis.
Methods: A comparative study was conducted on 25 VLBW infants hospitalized in neonatal intensive care units (NICU) of Hangzhou Women's Hospital in 2023. The infants were divided into the SMOF group (13 cases) and the soybean oil group (12 cases) based on the type of lipid emulsion used during parenteral nutrition.
Brain development using a multicomponent intravenous lipid emulsion in preterm infants.
BMC Pediatr
December 2024
Developing Brain Institute, Children's National Hospital, 111 Michigan Avenue, NW, Washington, DC, USA.
Background: Intravenous lipid emulsions are an essential component of nutritional support for very preterm infants. Many neonatal intensive care units have transitioned from traditional soybean oil-only to fish oil-containing multicomponent lipid emulsions, but the neurodevelopmental implications have not been well-explored. The primary aim of this study was to assess extrauterine third trimester brain growth in very preterm infants supported with soybean oil-only compared to fish-oil containing multicomponent lipid emulsions; white matter development and neurobehavioral regulation at term were also investigated.
View Article and Find Full Text PDFIntravenous Lipid Emulsion Therapy in Drug Overdose and Poisoning: An Updated Review.
Eurasian J Med
October 2024
Department of Medical Pharmacology, Gaziantep University Faculty of Medicine, Gaziantep, Türkiye.
The use of intravenous lipid emulsion (ILE) is thought to reverse the acute neurological and cardiac toxicities generated by local anesthetic and non-anesthetic drugs. The aim of this review is to provide an updated overview of ILE therapy in the management of the toxic efects of medications on humans. Indications, mechanisms of action, monitoring, dosing, lipid formulations, adverse efects, and contraindications related to ILE are highlighted.
View Article and Find Full Text PDFIntestinal failure-associated liver disease model: a reduced phytosterol intravenous lipid emulsion prevents liver injury.
Pediatr Res
November 2024
Vascular Biology Program and the Department of Surgery, Boston Children's Hospital, Boston, MA, USA.
Background: Long-term parenteral nutrition in children often results in intestinal failure-associated liver disease (IFALD). Phytosterols are plant steroids in vegetable oil-based intravenous lipid emulsions (ILEs) that are associated with IFALD. We investigated whether a phytosterol-depleted soybean oil ILE, compared to standard soybean oil ILE, prevented hepatotoxicity in a murine IFALD model.
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