Background: When possible, surgery is the treatment of choice for cutaneous carcinomas, as it allows to us perform the anatomopathological study and control the surgical margins. Mohs micrographic surgery (MMS) controls 100% of the margins, maintains a larger amount of healthy tissue, and a fewer number of recurrences are seen. Large limb surgical defects after MMS are a challenge. Within the different kind of flaps, the keystone flap, which is a fasciocutaneous island advancement flap, is an option.
Methods: A descriptive study was carried out on the extremity defects that occurred after MMS, which were reconstructed with the modified keystone type flap, during the years 2013-2014 in our department.
Results: Six patients underwent reconstruction surgery with the modified keystone flap. The tumor types presented by the patients were four squamous cell carcinomas and two basal cell carcinomas. Locations of the repaired defects were three in the leg, two in the thigh, and one in the forearm. The average size of the repaired defects was 3.1 cm. The procedure was well tolerated in all cases. No complications were observed, such as postoperative bleeding, infection, or necrosis, or dehiscence of the suture.
Conclusions: The modified keystone flap has been very helpful for solving the limb defects of these six patients, although they were not compared with other types of reconstruction.
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http://dx.doi.org/10.1111/ijd.13368 | DOI Listing |
Colloids Surf B Biointerfaces
April 2025
The National Research Centre for the Working Environment, Lersø Parkallé 105, Copenhagen DK-2100, Denmark. Electronic address:
Within the deep lung, pulmonary surfactant coats the air-liquid interface at the surface of the alveoli. This complex mixture of amphiphilic molecules and proteins modifies the surface tension and mechanical properties of this interface to assist with breathing. In this study, we examine the effects on pulmonary surfactant function by two industrially used compounds composing surfactants and polymers.
View Article and Find Full Text PDFEcol Appl
January 2025
Department of Biodiversity, Ecology and Evolution, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.
Livestock grazing and trampling have been shown to reduce arthropod populations. Among arthropods, defoliating lepidopterans are particularly important for their impact on trees, the keystone structures of agroforestry systems. This study investigates the impact of livestock on the community of defoliating lepidopterans in agroforestry systems.
View Article and Find Full Text PDFGenes (Basel)
November 2024
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.
Chemical fumigation can effectively inhibit the occurrence of soil-borne diseases; however, this approach can negatively affect the structure of the soil microbial community. The combination of soil fumigant and organic fertilizer application thus represents a widely adopted strategy in agricultural practice. Traditional Chinese medicine residue (TCMR) is a high-quality organic fertilizer; however, the impact of post-fumigation TCMR application on keystone taxa and their functional traits remains uncertain.
View Article and Find Full Text PDFIndian J Plast Surg
December 2024
Department of Plastic Reconstructive Surgery, ASST Valle Camonica, Esine, Brescia, Italy.
The keystone design perforator island flap (KDPIF) was first described by Behan in 2003 as a pliable flap, suitable for all body areas thanks to its curvilinear shape, which made it apt to fit mostly all cutaneous defects. In this article, we aim to share our experience using KDPIF for the reconstruction of different defects. A retrospective analysis of patients who underwent cutaneous excision after trauma or tumor resection and reconstruction with a KDPIF at our department from 2020 to 2023 was performed.
View Article and Find Full Text PDFInt J Food Microbiol
February 2025
College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, China. Electronic address:
Daqu is a wheat-based fermentation starter essential for Chinese Baijiu production. The storage of daqu critically influences its quality. However, the assembly mechanisms of microbial communities in daqu during the storage phase and their impact on volatile flavor compounds remain unclear.
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