[Relationship between Obesity, Adipokines and Systemic Lupus Erythematosus].

Rev Fac Cien Med Univ Nac Cordoba

Grupo de Inmunología Celular e Inmunogenética, Universidad de Antioquia, Medellín, Colombia.

Published: January 2017

Obesity is a pro-inflammatory state characterized by phenotypic changes in macrophages, alterationson cytokines balance, and increasing expression of regulatory molecules of the immune system derived from adipocytes and adipose tissue macrophages - also known as adipokines. Currently, leptin, adiponectin and resistin are, among others, one of the most known adipokines. Theseadipokinesmight play a possible role in systemic lupus erythematosus pathogenesis, by promotingdifferent pro-inflammatory conditions. Adipokines represent a possible treatment target in patients with lupus.

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