Apocynaceae is a large family of tropical trees, shrubs and vines with most species producing white latex. Major metabolites of species are triterpenoids, iridoids, alkaloids and cardenolides, which are known for a wide range of biological and pharmacological activities such as cardioprotective, hepatoprotective, neuroprotective, anti-inflammatory, anticancer and antimalarial properties. Prompted by their anticancer and antimalarial properties, the current knowledge on ten genera (Allamanda, Alstonia, Calotropis, Catharanthus, Cerbera, Dyera, Kopsia, Nerium, Plumeria and Vallaris) is updated. Major classes of metabolites are described using some species as examples. Species with antiproliferative (APF) and/or antiplasmodial (APM) properties have been identified. With the exception of the genus Dyera, nine genera of 22 species possess APF activity. Seven genera (Alstonia, Calotropis, Catharanthus, Dyera, Kopsia, Plumeria and Vallaris) of 13 species have APM properties. Among these species, Alstonia angustiloba, Alstonia macrophylla, Calotropis gigantea, Calotropis procera, Catharanthus roseus, Plumeria alba and Vallaris glabra displayed both APF and APM properties. The chemical constituents of these seven species are compiled for assessment and further research.
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http://dx.doi.org/10.1016/S2095-4964(16)60261-3 | DOI Listing |
Nat Commun
January 2025
State Key Laboratory of Precision Geodesy, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China.
Interplay between seismic and aseismic slip could shed light on the frictional properties and seismic potential of faults. The well-recorded 2023 Kahramanmaraş earthquake doublet provides an excellent opportunity to understand their partitioning on strike-slip faults. Here, we utilize InSAR and strong motion data to derive the coseismic rupture during the doublet, ~4-month postseismic afterslip, and slip distributions of two Mw>6.
View Article and Find Full Text PDFMolecules
December 2024
Institute of Food Sciences, Faculty of Biotechnology and Food Science, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, Slovakia.
The aim of this study was to investigate the effect of the addition of wild garlic leaves on the sensory quality, volatiles, color, and texture of sheep milk soft rennet-curd cheese. The sensory evaluation of color, appearance, texture, odor, and taste was performed using a 5-point scale. The intensity of selected taste and odor discriminants was also assessed.
View Article and Find Full Text PDFMaterials (Basel)
December 2024
Centre of Materials and Building Technologies (C-MADE), Department of Civil Engineering and Architecture, University of Beira Interior (UBI), 6201-001 Covilhã, Portugal.
The paper examines the impact of passive restraint on fire-induced spalling in concrete, utilizing a concrete mixture to minimize compositional variability. A variety of specimen geometries was prepared, including standard cubes and cylinders for the determination of mechanical properties and slabs of different dimensions for fire spalling tests conducted under controlled conditions. A top-opening Dragon furnace, which applies ISO 834-1 fire curves, was used to evaluate the influence of "cold rim" boundaries, where slab edges were insulated to create thermal restraint.
View Article and Find Full Text PDFJ Neurol Sci
January 2025
The University of Texas Southwestern Medical Center, Department of Neurology, Neuroinnovation Program, Multiple Sclerosis & Neuroimmunology Imaging Program, Dallas, TX, USA; The University of Texas Southwestern Medical Center, Peter O'Donnell Jr. Brain Institute, Dallas, TX, USA. Electronic address:
Background: Neuromyelitis optica spectrum disorder (NMOSD) is a commonly misdiagnosed condition. Driven by cost-consciousness and technological fluency, distinct generations may gravitate towards healthcare alternatives, including artificial intelligence (AI) models, such as ChatGPT (Generative Pre-trained Transformer). Our objective was to evaluate the speed and accuracy of ChatGPT-3.
View Article and Find Full Text PDFAppl Psychol Meas
December 2024
Umeå University, Sweden.
Modifications of current psychometric models for analyzing test data are proposed that produce an additive scale measure of information. This information measure is a one-dimensional space curve or curved surface manifold that is invariant across varying manifold indexing systems. The arc length along a curve manifold is used as it is an additive metric having a defined zero and a version of the bit as a unit.
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