Antipyrine test has been used to assess drug metabolism of the liver in 43 subjects, including 20 patients suffering from eczema and allergic dermatitis. "Rapid" oxidizers predominated among the patients; tissue barrier permeability for the test agent has been increased in eczema patients. These data should be borne in mind when prescribing the drugs that are subjected mainly to oxidizing metabolism, primarily antiinflammatory agents, to patients suffering from allergic dermatoses.
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