[Clinico-pharmacologic study on the liquid form of nifedipine in treating hypertensive crisis].

33 patients with hypertensive crisis were treated with a 2% Nifedipine solution for oral use. 5 patients had taken 5 mg, 16 patients--10 mg and 12 patients--20 mg of the drug. The antihypertensive action was followed up to the 6-th hour. The results show that the antihypertensive action of Nifedipine in doses of 5, 10 and 20 mg begins on the 5-th minute. The maximum antihypertensive action of these three doses is manifested between the 15 and 30 min. The duration of Nifedipine action in a dose of 5 mg is up to the 2-d hour and that of 10 and 20 mg doses is up to the 6-th hour. Only the 20 mg dose leads to a transitory statistically significant increase of the pulse rate with 10-12(-1) (p less than 0.05) between the 15 and 30 min. The side effects of the three doses are insignificant.