Spectral depth-profiling of optically turbid samples is of high interest to a broad range of applications. We present a method for measuring spatially-offset Raman spectroscopy (SORS) over a range of length scales by incorporating a digital micro-mirror device (DMD) into a sample-conjugate plane in the detection optical path. The DMD can be arbitrarily programmed to collect/reject light at spatial positions in the 2D sample-conjugate plane, allowing spatially offset Raman measurements. We demonstrate several detection geometries, including annular and simultaneous multi-offset modalities, for both macro- and micro-SORS measurements, all on the same instrument. Compared to other SORS modalities, DMD-based SORS provides more flexibility with only minimal additional experimental complexity for subsurface Raman collection.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1364/OE.24.012701 | DOI Listing |
Pharmaceuticals (Basel)
December 2024
College of Science and Engineering, Flinders University, Bedford Park, South Australia 5042, Australia.
Two fibre optic probes were custom designed to perform Raman and near-infrared spectroscopic measurements. Our long-term objective is to develop a non-destructive tool able to collect data in hard-to-access locations for real-time analysis or diagnostic purposes. This study evaluated the quantitative performances of Probe A and Probe B using model pharmaceutical tablets.
View Article and Find Full Text PDFJ Biophotonics
December 2024
Department of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, USA.
We report on the development of a multimodal spectroscopy system, combining diffuse reflectance spectroscopy (DRS) and spatially offset Raman spectroscopy (SORS). A fiber optic probe was designed with spatially offset source-detector fibers to collect subsurface measurements for each modality, as well as ball lens-coupled fibers for superficial measurements. The system acquires DRS, zero-offset Raman spectroscopy (RS) and SORS with good signal-to-noise ratio.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
December 2024
Institute of Heritage Science, National Research Council (CNR ISPC), Via Cozzi 53, 20125 Milano, Italy. Electronic address:
The preservation of paper-based archival documents is crucial for safeguarding historical and cultural heritage. Some records possess visually inaccessible text or images because of previous conservation measures, their method of construction, or historic damage. Micro-spatially Offset Raman Spectroscopy (micro-SORS) has emerged as a promising method for probing below or through opaque material substrates non-invasively.
View Article and Find Full Text PDFPathogens
November 2024
Department of Medical Physics, Faculty of Medicine, University of Ioannina, 451 10 Ioannina, Greece.
J Biophotonics
December 2024
Institute of Medical Chip, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Diabetes management often involves invasive blood glucose monitoring, which can be uncomfortable for patients. Non-invasive techniques like multiple μ-spatially offset Raman spectroscopy (mμSORS) offer a promising alternative. To provide clinical data supporting mμSORS, we conducted a clinical trial with 198 participants to evaluate mμSORS for non-invasive blood glucose measurement.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!