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Improving the image quality of short-time bone SPECT using cadmium-zinc-telluride detectors with SwiftScan.
Asia Ocean J Nucl Med Biol
January 2025
Department of Nuclear Medicine, Saitama Medical University Hospital, Saitama, Japan.
Article Synopsis
- This study examined the effectiveness of bone SPECT imaging with and without SwiftScan technology in patients with prostate cancer bone metastases.
- Involving 10 patients and 130 metastatic lesions, the research compared the quality of images produced at various acquisition times, showcasing improved quality scores and correlation coefficients with SwiftScan.
- Findings indicated that SwiftScan allowed for a 50% reduction in acquisition time while still maintaining acceptable image quality and accurate quantitative measurements like SUV and contrast-to-noise ratios.
Synchronous primary tumors amd distant metastasis detected on F-FDG PET in patients with head and neck carcinoma.
Asia Ocean J Nucl Med Biol
January 2025
Department of Nuclear medicine, Dr Rajendra Prasad Government medical college,Tanda Kangra Himachal Pradesh, India.
Article Synopsis
- The study focuses on the effectiveness of F-FDG PET/CT in identifying distant metastasis and synchronous tumors in newly diagnosed head and neck cancer patients in North India.
- A total of 281 patients were analyzed, revealing that 11.7% had distant metastases, primarily found in the lungs and bones, while 7% had synchronous malignancies, with lung cancer being the most common.
- These results support the use of whole body F-FDG PET/CT for initial staging as it significantly impacts patient management by detecting additional malignancies early on.
Time-of-flight PET/CT suppresses CT based attenuation correction and scatter coincidence correction errors due to misalignment of the gastrointestinal tract.
Asia Ocean J Nucl Med Biol
January 2024
Hirosaki University Graduate School of Health Sciences, Hirosaki-shi, Aomori, Japan.
Objectives: This study aimed to examine the influence of changes in CT values on PET images, specifically focusing on errors in CT-based attenuation correction and scatter coincidence correction (CTAC/SC) caused by gastrointestinal gas. Furthermore, it aimed to demonstrate the effectiveness of time-of-flight (TOF) PET in reducing CTAC/SC errors.
Methods: PET images were reconstructed using multiple CT images with varying CT values.
On the Optimization of the Protocol for Automated Radiosyntheses of [Ga]Ga-Pentixafor, [Ga]Ga-FAPI-4 and [Ga]Ga-DOTATATE in a Modular-Lab Standard.
Asia Ocean J Nucl Med Biol
January 2024
Homi Bhabha National Institute, Mumbai, India.
Objectives: The present work describes the automated radiochemical synthesis of different PET tracers like [Ga]Ga-Pentixafor, [Ga]Ga-FAPI-4 and [Ga]Ga-DOTATATE using optimized single protocol in the non-cassette based Eckert & Ziegler (EZ) Modular Lab (fixed tubing system) without any modification in the inbuilt human machine interface (HMI) software. Recently, PET agents viz. [Ga]Ga-Pentixafor and [Ga]Ga-FAPI-4 are gaining prominence for the diagnosis of overexpressed Chemokine Receptor-4 (CXCR4) and Fibroblast Activation Protein (FAP) receptor, respectively, in the microenvironment of numerous cancer types.
View Article and Find Full Text PDF[Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants.
Asia Ocean J Nucl Med Biol
January 2023
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
[Ga] Ga-labeled C-X-C motif receptor4 as a novel radio-ligand using PET/CT has been investigated for tracing various kinds of solid and hematopoietic malignancies in recent years. High-grade Glioma (WHO classification 2016 grade III and IV) shows elevated levels of CXCR4 ligand expression in the affected tumoral cells. Healthy and non-affected organ cells express low-level CXCR4 ligands density.
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